lysyl oxidase

By Targets:	Monoamine Oxidase (15) Akt (1) EGFR (1) Endogenous Metabolite (2) TGF-beta/Smad (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Inflammation/Immunology (7) Metabolic Disease (2)

Targets Recommended: Xanthine Oxidase NADPH Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138625

LOX-IN-3	Monoamine Oxidase	Cancer
LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research .

HY-138625A

LOX-IN-3 dihydrochloride	Monoamine Oxidase	Cancer
LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research .

HY-P99047

Simtuzumab AB 0024; GS 6624	Monoamine Oxidase	Inflammation/Immunology Cancer
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC) .

HY-Y1750

β-Aminopropionitrile 1 Publications Verification BAPN	Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

HY-124674A

CCT365623 hydrochloride 1 Publications Verification	Monoamine Oxidase EGFR Akt TGF-beta/Smad	Cancer
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor, with an IC₅₀ of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF. CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties .

HY-130242

PXS-5120A	Monoamine Oxidase	Inflammation/Immunology
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (K_i of 83 nM; pIC₅₀ of 8.4) over LOXL (pIC₅₀ of 5.8) .

HY-138625B

LOX-IN-3 dihydrochloride monohydrate	Monoamine Oxidase	Cardiovascular Disease Cancer
LOX-IN-3 dihydrochloride monohydrate (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride monohydrate can be used for fibrosis, cancer and angiogenesis research .

HY-Y1750A

β-Aminopropionitrile hydrochloride BAPN hydrochloride	Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .

HY-151498

PXS-4787	Monoamine Oxidase	Others
PXS-4787 is a specific and effective pan-LOX (lysyl *oxidase) inhibitor for abolishing lysyl* oxidase activity. PXS-4787 inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively .

HY-114286

PXS-5153A	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis.

HY-114286A

PXS-5153A monohydrochloride	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis.

HY-107422

Lenumlostat 1 Publications Verification PAT-1251; GB2064	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases .

HY-107422A

Lenumlostat hydrochloride PAT-1251 hydrochloride; GB2064 hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.

HY-151499

PXS-6302	Monoamine Oxidase	Others
PXS-6302 is an irreversible **lysyl oxidase inhibitor with IC₅₀**s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance .

HY-151499A

PXS-6302 hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PXS-6302 hydrochloride is an irreversible **lysyl oxidase inhibitor with IC₅₀**s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance .

Cat. No.	Product Name	Target	Research Area

HY-P99047

Simtuzumab AB 0024; GS 6624	Monoamine Oxidase	Inflammation/Immunology Cancer
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P99047

Simtuzumab AB 0024; GS 6624	Classification of Application Fields Disease Research Fields Cancer	Monoamine Oxidase
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC) .

HY-Y1750

β-Aminopropionitrile 1 Publications Verification BAPN	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

HY-Y1750A

β-Aminopropionitrile hydrochloride BAPN hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .

Species:	Human (3) Mouse (2)
Tag:	His (5)
Source:	HEK293 (2) CHO (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74771

	LOXL2 Protein, Human (CHO, His) lysyl oxidase homolog 2; lysyl oxidase-related protein WS9-14; LOXL2	Human	CHO
	LOXL2 protein mediates post-translational oxidative deamination of lysine residues, leading to the formation of allysine. It specifically deaminates H3K4me3, inhibits TFIID-dependent transcription, represses E-cadherin, activates the IRE1-XBP1 pathway, and promotes cross-linking of extracellular matrix proteins. LOXL2 is involved in EMT, tumor progression, angiogenesis regulation, and chondrocyte differentiation. LOXL2 Protein, Human (CHO, His) is the recombinant human-derived LOXL2 protein, expressed by CHO , with C-His labeled tag.

HY-P74769

	LOXL2 Protein, Mouse (HEK293, His) lysyl oxidase homolog 2; lysyl oxidase-related protein WS9-14; LOXL2	Mouse	HEK293
	LOXL2 proteins play multifaceted roles in cellular processes by mediating post-translational oxidative deamination of lysine residues, leading to lysine formation. As a transcriptional corepressor, it specifically deaminates histone H3 trimethylated at "Lys-4" (H3K4me3), which is associated with transcriptional activation. LOXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LOXL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74770

	LOXL2 Protein, Human (HEK293, His) lysyl oxidase homolog 2; lysyl oxidase-related protein WS9-14; LOXL2	Human	HEK293
	LOXL2 protein mediates post-translational oxidative deamination of lysine residues, leading to the formation of allysine. It specifically deaminates H3K4me3, inhibits TFIID-dependent transcription, represses E-cadherin, activates the IRE1-XBP1 pathway, and promotes cross-linking of extracellular matrix proteins. LOXL2 is involved in EMT, tumor progression, angiogenesis regulation, and chondrocyte differentiation. LOXL2 Protein, Human (HEK293, His) is the recombinant human-derived LOXL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71606

	Lysyl oxidase homolog 4 Protein, Mouse (His) Loxl4; Loxc; lysyl oxidase homolog 4; EC 1.4.3.-; lysyl oxidase-like protein 4; lysyl oxidase-related protein C	Mouse	E. coli
	LOXL4 Protein potentially modulates collagenous extracellular matrix formation, suggesting a role in regulating assembly or stability of collagen fibers. Its involvement indicates a contribution to the structural integrity of tissues. The specific mechanisms and contexts of LOXL4 in collagen matrix modulation are areas of interest, emphasizing its potential significance in tissue development and maintenance. Lysyl oxidase homolog 4 Protein, Mouse (His) is the recombinant mouse-derived Lysyl oxidase homolog 4 protein, expressed by E. coli , with N-His labeled tag.

HY-P702915

	LOXL4 Protein, Human (His) LOXC; lysyl oxidase-like 4	Human	E. coli
	LOXL4 Protein, Human (His) is the recombinant human-derived LOXL4, expressed by E. coli , with C-6*His labeled tag. ,

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HY-P83408

	LOX Antibody (YA3153) lox; LYOX; lysyl oxidase; Protein lysine 6 oxidase	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	LOX Antibody (YA3153) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3153), targeting LOX, with a predicted molecular weight of 47 kDa. LOX Antibody (YA3153) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P81861

	LOXL2 Antibody (YA1606) LOR2; LOX L2; LOXL2; lysyl oxidase homolog 2; lysyl oxidase like 2; WS9 14	WB, ICC/IF, FC	Human, Mouse, Rat
	LOXL2 Antibody (YA1606) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1606), targeting LOXL2, with a predicted molecular weight of 87 kDa. LOXL2 Antibody (YA1606) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.

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lysyl oxidase

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