2. Neuronal Signaling
  3. Monoamine Oxidase
  4. PXS-6302 hydrochloride

PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.

For research use only. We do not sell to patients.

PXS-6302 hydrochloride Chemical Structure

PXS-6302 hydrochloride Chemical Structure

CAS No. : 2584947-79-3

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Based on 1 publication(s) in Google Scholar

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PXS-6302 hydrochloride Related Antibodies

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Description

PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance[1].

In Vitro

PXS-6302 hydrochloride demonstrates high permeability to across a monolayer of cells, such as Caco-2 or MDCKII cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PXS-6302 hydrochloride Related Antibodies
In Vivo

PXS-6302 hydrochloride inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury[1].
PXS-6302 hydrochloride (1.5%, oil in water cream; 500 mg cream applied to 16 cm2; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application[1].
PXS-6302 hydrochloride (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Porcine excision injury model (female Juvenile pigs, 18-20 kg)[1].
Dosage: 0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2
Administration: External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result: Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance. Molecular Weight 265.25 Formula C10H10F3NO2S CAS No. 2584947-54-4 SMILES NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F Shipping Room temperature in continental US; may vary elsewhere. Storage Please store the product under the recommended conditions in the Certificate of Analysis. Purity & Documentation Data Sheet (270 KB)Handling Instructions (2659 KB) References [1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]
Molecular Weight

301.71

Formula

C10H11ClF3NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (331.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3144 mL 16.5722 mL 33.1444 mL
5 mM 0.6629 mL 3.3144 mL 6.6289 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3144 mL 16.5722 mL 33.1444 mL 82.8610 mL
5 mM 0.6629 mL 3.3144 mL 6.6289 mL 16.5722 mL
10 mM 0.3314 mL 1.6572 mL 3.3144 mL 8.2861 mL
15 mM 0.2210 mL 1.1048 mL 2.2096 mL 5.5241 mL
20 mM 0.1657 mL 0.8286 mL 1.6572 mL 4.1431 mL
25 mM 0.1326 mL 0.6629 mL 1.3258 mL 3.3144 mL
30 mM 0.1105 mL 0.5524 mL 1.1048 mL 2.7620 mL
40 mM 0.0829 mL 0.4143 mL 0.8286 mL 2.0715 mL
50 mM 0.0663 mL 0.3314 mL 0.6629 mL 1.6572 mL
60 mM 0.0552 mL 0.2762 mL 0.5524 mL 1.3810 mL
80 mM 0.0414 mL 0.2072 mL 0.4143 mL 1.0358 mL
100 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8286 mL
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PXS-6302 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PXS-63022584947-79-3PXS6302PXS 6302Monoamine OxidaseMAOskin treatmentpenetrating skincollagen depositionscar appearancescar tissuemurine models of injury and fibrosisporcine injury modelsInhibitorinhibitorinhibit

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