PXS-6302 hydrochloride

Name: PXS-6302 hydrochloride
Brand: MedChemExpress
SKU: HY-151499A
Rating: 4.5 (1 reviews)

Cat. No.: HY-151499A Purity: 99.83%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.

For research use only. We do not sell to patients.

PXS-6302 hydrochloride Chemical Structure

CAS No. : 2584947-79-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PXS-6302 hydrochloride:

PXS-6302 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

PXS-6302 hydrochloride demonstrates high permeability to across a monolayer of cells, such as Caco-2 or MDCKII cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PXS-6302 hydrochloride inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury^[1].
PXS-6302 hydrochloride (1.5%, oil in water cream; 500 mg cream applied to 16 cm²; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application^[1].
PXS-6302 hydrochloride (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm²; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Porcine excision injury model (female Juvenile pigs, 18-20 kg)^[1].
Dosage:	0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm²
Administration:	External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:	Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance. Molecular Weight 265.25 Formula C10H10F3NO2S CAS No. 2584947-54-4 SMILES NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F Shipping Room temperature in continental US; may vary elsewhere. Storage Please store the product under the recommended conditions in the Certificate of Analysis. Purity & Documentation Data Sheet (270 KB)Handling Instructions (2659 KB) References [1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]

Molecular Weight

301.71

Formula

C₁₀H₁₁ClF₃NO₂S

CAS No.

2584947-79-3

Appearance

Solid

Color

White to off-white

SMILES

NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (331.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3144 mL	16.5722 mL	33.1444 mL
5 mM	0.6629 mL	3.3144 mL	6.6289 mL
10 mM	0.3314 mL	1.6572 mL	3.3144 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (4.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (4.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (4.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (249 KB) HNMR (130 KB) RP-HPLC (169 KB) LCMS (271 KB)

Handling Instructions (2659 KB)

References

[1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3144 mL	16.5722 mL	33.1444 mL	82.8610 mL
	5 mM	0.6629 mL	3.3144 mL	6.6289 mL	16.5722 mL
	10 mM	0.3314 mL	1.6572 mL	3.3144 mL	8.2861 mL
	15 mM	0.2210 mL	1.1048 mL	2.2096 mL	5.5241 mL
	20 mM	0.1657 mL	0.8286 mL	1.6572 mL	4.1431 mL
	25 mM	0.1326 mL	0.6629 mL	1.3258 mL	3.3144 mL
	30 mM	0.1105 mL	0.5524 mL	1.1048 mL	2.7620 mL
	40 mM	0.0829 mL	0.4143 mL	0.8286 mL	2.0715 mL
	50 mM	0.0663 mL	0.3314 mL	0.6629 mL	1.6572 mL
	60 mM	0.0552 mL	0.2762 mL	0.5524 mL	1.3810 mL
	80 mM	0.0414 mL	0.2072 mL	0.4143 mL	1.0358 mL
	100 mM	0.0331 mL	0.1657 mL	0.3314 mL	0.8286 mL