Sodium metatungstate hydrate  (Synonyms: Sodium polyoxotungstate hydrate; POM-1 hydrate)

Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is a NTPDase inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively^[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission^[1][2][3][4].

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)^[1].

Sodium metatungstate hydrate (100 μM, 15 min) inhibits the ATP-induced uptake of anionic dyes and the large ATP-induced channels in macrophage^[2].
Sodium metatungstate hydrate (100 μM, 8 h) inhibits ATP-induced P2X7-associated pyroptosis in macrophage^[2].
Sodium metatungstate hydrate (100 μM, 8-24 h) has a potent anti-inflammatory effect on macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium metatungstate hydrate (5 mg/kg, Intraperitoneal injection, single dose) shows different cytokine/chemokine responses in the peritoneum and systemically in the bloodstream in CD39 knockout mice^[3].
Sodium metatungstate hydrate (5 mg/kg, Intraperitoneal injection, once per day from 0 to day 4, day 7-11, and day 14-18.) combine with anti-CD73 antibody and AZD4635(HY-101980) reduces tumor load in multiple myeloma (MM) mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2968 (anhydrous basis)

3Na₂WO₄.9WO₃.xH₂O

314075-43-9

[Na+].O=[W+4]1234[O-2][W+4]567(=O)[O-2][W+4]89%10(=O)[O-2][W+4]%11%12(=O)([O-2]1)[O-2][W+4]%13(=O)([O-2]8)([O-2][W+4]%14%15%16(=O)[O-2][W+4]%17(=O)([O-2]2)([O-2]%11)[O-2][W+4]%18(=O)([O-2][W+4](=O)([O-2]3)([O-2]5)([O-2][W+4]%19%20(=O)([O-2][W+4]%21(=O)([O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wall M J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition [J]. Neuropharmacology, 2008, 55(7): 1251-1258.  [Content Brief]

  [2]. Pimenta-dos-Reis G, et al. POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages [J]. Purinergic Signalling, 2017, 13: 611-627.  [Content Brief]

  [3]. Csóka B, et al. CD39 improves survival in microbial sepsis by attenuating systemic inflammation [J]. The FASEB Journal, 2015, 29(1): 25.  [Content Brief]

  [4]. Yang R, et al. Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade [J]. Journal for immunotherapy of cancer, 2020, 8(1).  [Content Brief]