2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel GPCR/G Protein Apoptosis Immunology/Inflammation
  3. Phosphatase P2X Receptor P2Y Receptor Pyroptosis Interleukin Related
  4. Sodium metatungstate

Sodium metatungstate  (Synonyms: Sodium polyoxotungstate; POM-1)

Cat. No.: HY-103259 Assay: 93.4%
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Sodium metatungstate (Sodium polyoxotungstate) est un inhibiteur puissant de la ecto-nucléoside triphosphate diphosphohydrolase (NTPDase), avec des valeurs Ki de 2,58 μM, 3,26 μM et 28,8 μM pour NTPDase 1, NTPDase 3 et NTPDase 2 respectivement. Sodium metatungstate inhibe la dégradation de l'ATP mais bloque également la transmission synaptique centrale, une action indépendante de l'inhibition de la NTPDase.

Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission.

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Sodium metatungstate Chemical Structure

Sodium metatungstate Chemical Structure

CAS No. : 12141-67-2

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Based on 6 publication(s) in Google Scholar

Other Forms of Sodium metatungstate:

Sodium metatungstate Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission[1][2][3][4].

IC50 & Target

IL-1β

 

P2X7 Receptor

 

In Vitro

Sodium metatungstate (100 μM, 15 min) inhibits the ATP-induced uptake of anionic dyes and the large ATP-induced channels in macrophage[2].
Sodium metatungstate (100 μM, 8 h) inhibits ATP-induced P2X7-associated pyroptosis in macrophage[2].
Sodium metatungstate (100 μM, 8-24 h) has a potent anti-inflammatory effect on macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium metatungstate Related Antibodies
In Vivo

Sodium metatungstate (5 mg/kg, Intraperitoneal injection, single dose) shows different cytokine/chemokine responses in the peritoneum and systemically in the bloodstream in CD39 knockout mice[3].
Sodium metatungstate (5 mg/kg, Intraperitoneal injection, once per day from 0 to day 4, day 7-11, and day 14-18.) combine with anti-CD73 antibody and AZD4635(HY-101980) reduces tumor load in multiple myeloma (MM) mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple myeloma (MM) mice developed by 3 weeks of injection of 5t33MM cells[4]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Had significantly lower spleen weights, fewer tumor cells in the spleen as well as significantly lower monoclonal immunoglobulin component level in circulation.
Molecular Weight

2986.01

Formula

H2Na6O40W12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[3Na2WO4.9WO3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (16.74 mM; Need ultrasonic)

DMSO : 50 mg/mL (16.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3349 mL 1.6745 mL 3.3490 mL
5 mM 0.0670 mL 0.3349 mL 0.6698 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (33.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.3349 mL 1.6745 mL 3.3490 mL 8.3724 mL
5 mM 0.0670 mL 0.3349 mL 0.6698 mL 1.6745 mL
10 mM 0.0335 mL 0.1674 mL 0.3349 mL 0.8372 mL
15 mM 0.0223 mL 0.1116 mL 0.2233 mL 0.5582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium metatungstate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium metatungstate12141-67-2Sodium polyoxotungstate POM-1POM1POM 1POM-1PhosphataseP2X ReceptorP2Y ReceptorPyroptosisInterleukin RelatedP2XRsILmacrophageCD39 knockout miceMultiple myeloma miceInhibitorinhibitorinhibit

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