2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX

COX

Cyclooxygenase

COX

Related Products

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Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Isoform Specific Products:

COX Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157578
    COX-2-IN-38
    		Inhibitor
    COX-2-IN-38 (compound 52*) is a potent inhibitor of COX-2, with the IC50 value of 79.4 nM.
    COX-2-IN-38
  • HY-B0531R
    Triflusal (Standard)
    		Inhibitor
    Triflusal (Standard) is the analytical standard of Triflusal. This product is intended for research and analytical applications.
    Triflusal (Standard)
  • HY-108162
    Ataquimast free base
    		Inhibitor
    Ataquimast free base is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast free base can be used in the study of advanced receptor-positive breast cancer.
    Ataquimast free base
  • HY-103388
    NCX 466
    		Inhibitor
    NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-β (TGF-β) and oxidative stress markers (such as thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase (MPO) activity, thereby preventing bleomycin (HY-108345)-induced pulmonary fibrosis in mice.
    NCX 466
  • HY-B0253R
    Piroxicam (Standard)
    		Inhibitor
    Piroxicam (Standard) is the analytical standard of Piroxicam. This product is intended for research and analytical applications. Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.
    Piroxicam (Standard)
  • HY-B0482R
    Acemetacin (Standard)
    		Inhibitor
    Acemetacin (Standard) is the analytical standard of Acemetacin. This product is intended for research and analytical applications. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
    Acemetacin (Standard)
  • HY-131260R
    Ibuprofen Impurity K (Standard)
    		Inhibitor
    Ibuprofen Impurity K (Standard) is the analytical standard of Ibuprofen Impurity K. This product is intended for research and analytical applications. Ibuprofen Impurity K is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    Ibuprofen Impurity K (Standard)
  • HY-137222S
    4',5-Dihydroxy Diclofenac-13C6
    		Inhibitor
    4',5-Dihydroxy Diclofenac-13C6 is a deuterated derivative of Diclofenac (HY-15036). Diclofenac is a potent COX inhibitor with anti-inflammatory activity.
    4',5-Dihydroxy Diclofenac-<sup>13</sup>C<sub>6</sub>
  • HY-14739R
    Choline Fenofibrate (Standard)
    		Inhibitor
    Choline Fenofibrate (Standard) is the analytical standard of Choline Fenofibrate. This product is intended for research and analytical applications. Choline Fenofibrate (ABT-335), a choline salt of Fenofibric acid (HY-B0760), releases free Fenofibric acid in the gastrointestinal tract. Fenofibric acid is a PPAR activator with antihyperlipidemic effect.
    Choline Fenofibrate (Standard)
  • HY-118078S
    Robenacoxib-d5
    		Inhibitor
    Robenacoxib-d5 is deuterium-labeled Robenacoxib (HY-118078).
    Robenacoxib-d<sub>5</sub>
  • HY-124481
    Oleocanthal
    		Inhibitor
    Oleocanthal is a COX-1/2 enzyme inhibitor and a nonsteroidal anti-inflammatory agent. Oleocanthal is obtained from virgin olive oil.
    Oleocanthal
  • HY-16726R
    Polmacoxib (Standard)
    		Inhibitor
    Polmacoxib (Standard) is the analytical standard of Polmacoxib. This product is intended for research and analytical applications. Polmacoxib (CG100649) is a first-in-class, orally active nonsteroidal anti-inflammatory agent (NSAID) which is a dual inhibitor of COX-2 (IC50 around 0.1 μg/ml) and carbonic anhydrase. Polmacoxib inhibits colorectal adenoma and tumor growth in mouse models.
    Polmacoxib (Standard)
  • HY-14670S
    Firocoxib-d4
    		Inhibitor
    Firocoxib-d4 (ML 1785713-d4) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects[1].
    Firocoxib-d<sub>4</sub>
  • HY-117368
    AL-8417
    		Inhibitor
    AL-8417 ((2R)-AL-5898) is a potent inhibitor of Cyclooxygenase (COX), with IC50 of 120 μM, that plays an important role in inflammatory response.
    AL-8417
  • HY-B0230R
    Phenylbutazone (Standard)
    		Inhibitor
    Phenylbutazone (Standard) is the analytical standard of Phenylbutazone. This product is intended for research and analytical applications. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.
    Phenylbutazone (Standard)
  • HY-118827S
    Vedaprofen-d3
    		Inhibitor
    Vedaprofen-d3 is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].
    Vedaprofen-d<sub>3</sub>
  • HY-149460
    Harmaline analog
    		Inhibitor
    Harmaline analog (compound 3) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.145 μM.
    Harmaline analog
  • HY-15123R
    (S)-Flurbiprofen (Standard)
    		Inhibitor
    (S)-Flurbiprofen (Standard) is the analytical standard of (S)-Flurbiprofen. This product is intended for research and analytical applications. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively.
    (S)-Flurbiprofen (Standard)
  • HY-106897
    BF389
    		Inhibitor
    BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research.
    BF389
  • HY-B0288A
    Fenoprofen Calcium
    		Inhibitor
    Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
    Fenoprofen Calcium
Cat. No. Product Name / Synonyms Application Reactivity
COX Isoform Comparison

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