BF389  (Synonyms: Biofor 389)

BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC₅₀s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research^[1][2][3].

BF389 inhibits the production of PGE2 and LTB4 formation with IC₅₀s of 0.84 μM and 3.65 μM respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BF389 (1-30 mg/kg, p.o., five daily oral doses) inhibits paw swelling in rats, with an ED₅₀ of 4.9 mg/kg, indicating the anti-inflammatory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

331.45

C₂₀H₂₉NO₃

127245-22-1

CC(C)(C1=C(C(C(C)(C)C)=CC(/C=C2C(N(OCC/2)C)=O)=C1)O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bendele AM, et al. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5.  [Content Brief]

  [2]. Wong S, et al. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8.  [Content Brief]

  [3]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.  [Content Brief]