Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (1522)
Antibodies (1)

By Effects:	Inhibitors (1380) Antagonists (3) Modulators (2) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-14273S

Isavuconazole-d₄	Inhibitor	99.88%
Isavuconazole-d₄ is a deuterium labeled Isavuconazole (BAL-4815). Isavuconazole is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi[1].

HY-N1198

Strictosamide	Inhibitor	99.98%
Strictosamide has important effects on inflammation and inflammatory pain. Strictosamide possesses antiplasmodial and antifungal activities.

HY-116214

Cyprodinil	Inhibitor	99.36%
Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC₅₀=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC₅₀=15.1 µM).

HY-19593

Nikkomycin Z	Inhibitor	98.62%
Nikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor. Nikkomycin Z has antifungal effects and acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine.

HY-121388

Ledol	Inhibitor	≥98.0%
Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting.

HY-N8432

Dipyrithione	Inhibitor	99.93%
Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.

HY-B2140

Multifungin	Inhibitor	99.92%
Multifungin (Bromochlorosalicylanilide) is an antifungal that treats oral *candidiasis*. Multifungin prevents the formation and accumulation of Zearalenone and reduces the fungal population in stored-crushed corn.

HY-B1151

Climbazole	Inhibitor	98.26%
Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.

HY-108450

Polygodial	Inhibitor	98.61%
Polygodial (Poligodial) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.

HY-W020182

α-Terpinene	Inhibitor
α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against *Trypanosoma evansi* and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties.

HY-17578

Pneumocandin B0	Inhibitor
Pneumocandin B0 (L-688786), the precursor of the antifungal agent Caspofungin acetate, is an antifungal agent belonging to the echinocandin family. Pneumocandin B0, derived from the flamentous fungus Glarea lozoyensis, is a synthetic intermediate of Cancidas.

HY-B1143

Broxaldine	Inhibitor	99.50%
Broxaldine (Brobenzoxaldine) is an antiprotozoal agent. Broxaldine inhibits *Clostridium difficile* with a MIC value of 4 µM, and has antifungal effects.

HY-B1134

Imazalil	Inhibitor	99.20%
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.

HY-119123A

Voxvoganan trihydrochloride	Inhibitor	98.13%
Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, is highly effective against S. aureus with a MIC range of 2 to 4 μg/mL. Voxvoganan trihydrochloride can be used for the research of bacterial skin infections, fungal infections and nasal decolonisation of MRSA.

HY-106541

Neticonazole	Inhibitor	99.58%
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.

HY-P3512

Iseganan	Inhibitor
Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research.

HY-B1144A

Chlormidazole hydrochloride	Inhibitor	98.98%
Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses.

HY-133704

Pyrrolnitrin	Inhibitor	98.03%
Pyrrolnitrin is an antibiotic isolated from Pseudomonas pyrrocinia. Pyrrolnitrin shows a broad spectrum of antibiotic activity against fungi, yeast and gram-positive bacteria.

HY-17373S1

Posaconazole-d₄	Inhibitor	99.04%
Posaconazole-d₄ is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].

HY-P0269

Magainin 1	Inhibitor	99.90%
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

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Fungal

Fungal

Fungal Related Products (1522)

Antibodies (1)

Fungal Related Products (1522):