2. Anti-infection
  3. Bacterial Fungal Antibiotic
  4. Magainin 1

Magainin 1  (Synonyms: Magainin I)

Cat. No.: HY-P0269 Purity: 99.90%
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Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Magainin 1 Chemical Structure

Magainin 1 Chemical Structure

CAS No. : 108433-99-4

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500 μg USD 84 In-stock
1 mg USD 144 In-stock
5 mg USD 360 In-stock
10 mg USD 560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Magainin 1:

Magainin 1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria[1][2][3].

In Vitro

Magainin 1 interacts with acidic lipids through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix, inducing the leakage. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8×105 M-1 and a binding-site number of 0.10 per lipid molecule[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Magainin 1 Related Antibodies
Molecular Weight

2409.85

Formula

C112H177N29O28S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser
Sequence Shortening

GIGKFLHSAGKFGKAFVGEIMKS
Structure Classification
Initial Source

Xenopus laevis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (41.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4150 mL 2.0748 mL 4.1496 mL
5 mM 0.0830 mL 0.4150 mL 0.8299 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4150 mL 2.0748 mL 4.1496 mL 10.3741 mL
5 mM 0.0830 mL 0.4150 mL 0.8299 mL 2.0748 mL
10 mM 0.0415 mL 0.2075 mL 0.4150 mL 1.0374 mL
15 mM 0.0277 mL 0.1383 mL 0.2766 mL 0.6916 mL
20 mM 0.0207 mL 0.1037 mL 0.2075 mL 0.5187 mL
25 mM 0.0166 mL 0.0830 mL 0.1660 mL 0.4150 mL
30 mM 0.0138 mL 0.0692 mL 0.1383 mL 0.3458 mL
40 mM 0.0104 mL 0.0519 mL 0.1037 mL 0.2594 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Magainin 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magainin 1108433-99-4Magainin IMagainin1Magainin-1BacterialFungalAntibioticAntimicrobialamphipathicpeptidelipidvesicleshydrophobicleakageInhibitorinhibitorinhibit

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