2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. DMDA-PatA

DMDA-PatA is a small-molecule eIF4A inhibitor that represses translation in an mRNA-selective and ATP-independent manner by clamping eIF4A, a DEAD-box RNA binding protein, onto GNG motifs. DMDA-PatA is promising for research of cancers and viral infections.

For research use only. We do not sell to patients.

DMDA-PatA Chemical Structure

DMDA-PatA Chemical Structure

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DMDA-PatA Related Antibodies

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Description

DMDA-PatA is a small-molecule eIF4A inhibitor that represses translation in an mRNA-selective and ATP-independent manner by clamping eIF4A, a DEAD-box RNA binding protein, onto GNG motifs. DMDA-PatA is promising for research of cancers and viral infections[1].

IC50 & Target

eIF4

 

Molecular Weight

526.73

Formula

C30H42N2O4S
SMILES

CC(/C=C/C(C)=C/[C@H](CC1=NC(CCCCC(O2)=O)=CS1)OC(/C=C\C=C(C[C@@H]2C)/C)=O)=C\CN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DMDA-PatA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMDA-PatAEukaryotic Initiation Factor (eIF)eIF4AtranslationGNG motifscancersviral infectionsInhibitorinhibitorinhibit

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