2. Gene
  3. DOCK11 - dedicator of cytokinesis 11 Gene

DOCK11 - dedicator of cytokinesis 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACG; ZIZ2; bB128O4.1

Gene ID: 139818 | Gene type: protein coding

About DOCK11

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,495,815-118,686,147 (from NCBI)

This gene has 4 transcripts (splice variants), 226 orthologues and 10 paralogues. Broad expression in fat (RPKM 20.0), lymph node (RPKM 11.7) and 19 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DOCK11 Products(1)

mRNA Protein Name
NM_144658.4 NP_653259.3 dedicator of cytokinesis protein 11

DOCK11 Protein Structure

DUF3398

DUF3398: Domain of unknown function (DUF3398) (51 - 145)

PH

PH: PH domain (166 - 271)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (635 - 827)

DHR-2

DHR-2: Dock homology region 2 (1852 - 2028)

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  • 2073 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 11

Activated Cdc42-associated guanine nucleotide exchange factor, ACG

Related Diseases

Diseases Alias
Viral Laryngitis
Brachydactyly, Type C

Brachydactyly Type C

BDC

Brachydactyly Haws Type

Brachydactyly, Haws Type

Brachydactyly C
Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03923 DOCK11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DOCK11 VGNC VGNC:40045
Felis catus DOCK11 VGNC VGNC:97404
Mus musculus DOCK11 MGD MGI:1923224
Bos taurus DOCK11 VGNC VGNC:28156
Rattus norvegicus DOCK11 RGD RGD:1564707
Macaca mulatta DOCK11 VGNC VGNC:71890