PLD6 - phospholipase D family member 6 Gene

Homo sapiens

Also known as ZUC

Gene ID: 201164 | Gene type: protein coding

About PLD6

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,200,995-17,206,333 (from NCBI)

This gene has 1 transcript (splice variant) and 180 orthologues. Broad expression in testis (RPKM 12.6), prostate (RPKM 3.8) and 25 other tissues.

Summary

Enables cardiolipin hydrolase activity and protein homodimerization activity. Involved in mitochondrial fusion. Acts upstream of or within positive regulation of mitochondrial fusion. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLD6 Products(1)

mRNA	Protein	Name
NM_178836.4	NP_849158.2	mitochondrial cardiolipin hydrolase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cardiolipin hydrolase activity	IDA IDA: Inferred from direct assay	17028579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26711011	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17028579	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	17028579	GOA
acts upstream of or within positive regulation of mitochondrial fusion	IDA IDA: Inferred from direct assay	24599962	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	17028579	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLD6 Protein Structure

PLDc_2

0
100
200
252 a.a.

Protein Preferred Names

Protein Names

mitochondrial cardiolipin hydrolase

PLD 6

Related Diseases

Diseases

Alias

Heavy Chain Disease

Hcd

Pinguecula

Conjunctival Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10675	PLD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLD6	VGNC	VGNC:76145
Rattus norvegicus	PLD6	RGD	RGD:1311987
Bos taurus	PLD6	VGNC	VGNC:33000
Mus musculus	PLD6	MGD	MGI:2687283
Felis catus	PLD6	VGNC	VGNC:99319
Canis familiaris	PLD6	VGNC	VGNC:53434

Name
Email *

	Sorry, but the email address you supplied was invalid.