ATOH1 - atonal bHLH transcription factor 1 Gene

Homo sapiens

Also known as ATH1; HATH1; MATH-1; bHLHa14

Gene ID: 474 | Gene type: protein coding

About ATOH1

Cytogenetic location: 4q22.2 Genomic coordinates (GRCh38): 4:93,828,753-93,830,964 (from NCBI)

This gene has 1 transcript (splice variant), 185 orthologues and 15 paralogues.

Summary

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

ATOH1 Products(1)

mRNA	Protein	Name
NM_005172.2	NP_005163.1	transcription factor ATOH1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATOH1 Protein Structure

HLH

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

transcription factor ATOH1

atonal homolog 1

Related Diseases

Diseases

Alias

Goblet Cell Carcinoid

Gcc	Goblet Cell Adenocarcinoid
Goblet Cell Carcinoma	Goblet Cell Tumor
Mucinous Carcinoid	Carcinoid Goblet Cell
Carcinoid, Goblet Cell

Cerebellar Liponeurocytoma

Lipomatous Medulloblastoma

Central Neurocytoma

Usher Syndrome, Type Iiia

Usher Syndrome Type 3	Ush3
Usher Syndrome Type 3a	USH3A
Usher Syndrome, Type Iii	Usher Syndrome, Type 3
Usher Syndrome, Type 3a	Usher Syndrome Type Iiia
Usher Syndrome 3a	Usher'S Syndrome Type 3
Usher Syndrome Iii	Usher Syndrome Type Iii

Deafness, Autosomal Dominant 15

DFNA15	Autosomal Dominant Nonsyndromic Deafness 15
Autosomal Dominant Deafness 15	Deafness, Autosomal Dominant, 15
Deafness, Autosomal Dominant, Type 15

Cerebellum Cancer

Cerebellar Neoplasms	Cerebellar Cancer
Malignant Tumor Of Cerebellum	Malignant Neoplasm Of Cerebellum

Cerebellar Medulloblastoma

Viral Labyrinthitis

Epidemic Vertigo

Vestibular Neuronitis

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Adult Cns Pnet

Adult Central Nervous System Primitive Neuroectodermal Tumor

Drug-Induced Hearing Loss

Drug Induced Hearing Loss

Labyrinthitis

Labyrinthine Disorder	Inner Ear Inflammation
Otitis Interna	Labyrinth Hyperaemia

Infratentorial Cancer

Infratentorial Neoplasms	Brain Neoplasm, Infratentorial
Malignant Infratentorial Tumors

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Inner Ear Disease

Labyrinthine Dysfunction	Diseases Of Inner Ear
Labyrinthine Disease	Abnormality Of The Inner Ear
Labyrinth Diseases	Labyrinthine Disorder
Nonfunctioning Labyrinth	Labyrinthine Loss Of Function
Labyrinthine Syndrome	Labyrinthine Disorder Nos

Childhood Medulloblastoma

Medulloblastoma, Childhood	Pediatric Medulloblastoma
Medulloblastoma Childhood

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Deafness, Aminoglycoside-Induced

Streptomycin Ototoxicity	Deafness, Mitochondrial, Modifier Of
Aminoglycoside-Induced Deafness	Deafness, Streptomycin-Induced
Streptomycin-Induced Deafness	DFNI

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Otosclerosis

Otospongiosis

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01165	ATOH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATOH1	MGD	MGI:104654
Rattus norvegicus	ATOH1	RGD	RGD:1565171
Bos taurus	ATOH1	VGNC	VGNC:26270
Felis catus	ATOH1	VGNC	VGNC:107311
Macaca mulatta	ATOH1	VGNC	VGNC:70174
Canis familiaris	ATOH1	VGNC	VGNC:38235

Name
Email *

	Sorry, but the email address you supplied was invalid.