2. Gene
  3. NEO1 - neogenin 1 Gene

NEO1 - neogenin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NGN; IGDCC2; NTN1R2

Gene ID: 4756 | Gene type: protein coding

About NEO1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,051,692-73,305,206 (from NCBI)

This gene has 11 transcripts (splice variants), 244 orthologues and 36 paralogues. Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues.

Summary

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

NEO1 Products(3)

mRNA Protein Name
NM_001172623.1 NP_001166094.1 neogenin isoform 2 precursor
NM_001172624.1 NP_001166095.1 neogenin isoform 3 precursor
NM_002499.4 NP_002490.2 neogenin isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables co-receptor binding IPI
IPI: Inferred from physical interaction
18335997 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18335997 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within multicellular organismal-level iron ion homeostasis IGI
IGI: Inferred from genetic interaction
16075058 GOA
Cellular Component GO Annotation Evidence Reference Source
part of plasma membrane protein complex IDA
IDA: Inferred from direct assay
18335997 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEO1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (65 - 147)

I-set

I-set: Immunoglobulin I-set domain (152 - 239)

I-set

I-set: Immunoglobulin I-set domain (250 - 337)

I-set

I-set: Immunoglobulin I-set domain (341 - 427)

fn3

fn3: Fibronectin type III domain (440 - 525)

fn3

fn3: Fibronectin type III domain (543 - 618)

fn3

fn3: Fibronectin type III domain (636 - 720)

fn3

fn3: Fibronectin type III domain (742 - 818)

fn3

fn3: Fibronectin type III domain (856 - 942)

fn3

fn3: Fibronectin type III domain (956 - 1044)

Neogenin_C

Neogenin_C: Neogenin C-terminus (1156 - 1461)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1461 a.a.
Protein Preferred Names Protein Names

neogenin

immunoglobulin superfamily DCC subclass member 2

Recombinant NEO1 Proteins

Cat. No. Product Name Accession Purity
HY-P701081 Neogenin Protein, Human (HEK293, hFc) Q92859-1 (A34-L1105) ≥95%

Related Diseases

Diseases Alias
Corneal Intraepithelial Neoplasm
Hemochromatosis Type 2

Juvenile Hemochromatosis

Juvenile Hereditary Hemochromatosis

Hfe2

Jhh

Hemochromatosis Juvenile

Iron Overload Disease Juvenile

Hemochromatosis, Juvenile

Hemochromatosis, Type 2

Hemochromatosis

Hemochromatosis, Type 1
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH

Bone Dysplasia With Medullary Fibrosarcoma

Bdmf

Bone Dysplasia With Malignant Fibrous Histiocytoma

Hardcastle Syndrome

Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome

Myopathy, Limb-Girdle, With Bone Fragility

Bone Dysplasia-Medullary Fibrosarcoma Syndrome

Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome

Dms-Mfh

Limb-Girdle Myopathy With Bone Fragility

Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

Dysequilibrium Syndrome

CAMRQ1

Des

Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1

Cerebellar Hypoplasia, Vldlr-Associated

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome

Uner Tan Syndrome

Vldlr Cerebellar Hypoplasia

Vldlrch

Vldlr-Associated Cerebellar Hypoplasia

Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive

Camrq

Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1

Cerebellar Disorder, Nonprogressive, With Intellectual Disability

Cerebellar Hypoplasia, Vldlr Associated

Autosomal Recessive Cerebellar Ataxia With Mental Retardation

Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification

Cerebellar Disorder, Nonprogressive, With Mental Retardation

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion

Chmrq1

Des-Vldlr

Dysequilibrium Syndrome-Vldlr

Vldlr-Ch

Camrq Syndrome

Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome

Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome

Uts

Cerebellar Hypoplasia Vldlr-Associated

Dialysis Disequilibrium Syndrome
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09209 NEO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NEO1 VGNC VGNC:32007
Rattus norvegicus NEO1 RGD RGD:619837
Felis catus NEO1 VGNC VGNC:80901
Macaca mulatta NEO1 VGNC VGNC:75314
Mus musculus NEO1 MGD MGI:1097159
Canis familiaris NEO1 VGNC VGNC:43745
Others NEO1 NCBI