2. Academic Validation
  3. Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain

Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain

  • Eur J Pharmacol. 1992 Oct 6;221(1):139-43. doi: 10.1016/0014-2999(92)90783-z.
A Tvrdeić 1,  D Pericić
Affiliations

Affiliation

  • 1 Ruder Bosković Institute, Laboratory for Molecular Neuropharmacology, Zagreb, Croatia.
PMID: 1333969 DOI: 10.1016/0014-2999(92)90783-z
Abstract

Dihydroergotoxine non-competitively displaced the binding of t-[3H]butylbicycloorthobenzoate ([3H]TBOB) to crude synaptosomal membranes from the mouse brain (cerebrum minus cortex), and gamma-aminobutyric acid (GABA) (10 microM) enhanced the displacement potency of dihydroergotoxine in a bicuculline-sensitive manner. The same ergot compound prolonged pentobarbital-induced sleeping in mice and diminished the convulsive potency of picrotoxin in the same animal species. The results are indicative of the positive coupling between GABA and dihydroergotoxine.

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