bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His)

The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag and E1454Q, , , , mutation. The total length of bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is 1530 a.a., .

bABCC1 Protein assumes a pivotal role in cellular physiology by mediating the export of organic anions and diverse drugs from the cytoplasm. This multifunctional transporter facilitates the ATP-dependent transport of various substrates, including glutathione and its conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, and antiviral drugs. Remarkably, bABCC1 confers resistance to anticancer drugs by actively reducing the intracellular accumulation of these agents through ATP- and GSH-dependent drug export mechanisms. Despite its relatively low efficiency in ATP hydrolysis, bABCC1 plays a crucial role in exporting sphingosine 1-phosphate from mast cells independently of degranulation, and also participates in the inflammatory response by facilitating the export of leukotriene C4 from cells involved in leukotriene C4 synthesis. Additionally, bABCC1 mediates ATP-dependent, GSH-independent export of cyclic GMP-AMP (cGAMP), thus acting as a negative regulator of the cGAS-STING pathway by limiting intracellular cGAMP concentrations. The broad spectrum of substrates and its impact on drug resistance underscore the importance of bABCC1 in cellular homeostasis and therapeutic response, warranting further investigation into its precise molecular mechanisms and therapeutic implications.

Human

HEK293

C-10*His;C-GFP;C-Strep

Q8HXQ5 (M1-V1530, E1454Q)

281588

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.