2. Recombinant Proteins
  3. CD Antigens Receptor Proteins
  4. Epithelial cell CD Proteins Endothelial cell CD Proteins Notch family
  5. Jagged-1/CD339
  6. Jagged-1/JAG1 Protein, Human (HEK293, His, solution)

Jagged-1/JAG1 Protein, Human (HEK293, His, solution)

Cat. No.: HY-P701016
Handling Instructions

Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Description

Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-His labeled tag.
Background

The Jagged-1 (JAG1) protein functions as a ligand for multiple Notch receptors, playing a crucial role in mediating Notch signaling, as evidenced by its interactions with NOTCH1, NOTCH2, and NOTCH3. Its involvement in cell-fate decisions during hematopoiesis suggests a regulatory role in blood cell development. JAG1 is implicated in various stages of mammalian cardiovascular development and has been associated with both early and late phases of this process. Additionally, it inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis in vitro. Notably, the interaction between JAG1 and NOTCH1 is calcium ion-dependent, highlighting the complexity of its regulatory mechanisms in cellular processes.
Species

Human
Source

HEK293
Tag

C-His
Accession

P78504-1 (Q34-S1046)
Gene ID

/
Molecular Construction
N-term
JAG1 (Q34-S146)
Accession # P7854-1
hFc
C-term
Synonyms
Jagged1; hJ1; CD339; JAGL1; AGS; AHD; AWS
Molecular Weight

120-140 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Jagged-1/JAG1 Protein, Human (HEK293, His, solution) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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