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Results for "

(±)-Orphenadrine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholinesterase (ChE) (1) Cytochrome P450 (1) Drug Metabolite (1) iGluR (6) Isotope-Labeled Compounds (3)
By Research Areas:	Cancer (3) Neurological Disease (6)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157959

*Orphenadrine* (±)-Orphenadrine	iGluR Cytochrome P450 Cholinesterase (ChE)	Neurological Disease Cancer
Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of ^[3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and cytochrome P450 (CYP) 2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation .

HY-B0369A

Orphenadrine citrate	iGluR	Neurological Disease Cancer
Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-143861S

Orphenadrine-d3	Isotope-Labeled Compounds	Others
Orphenadrine-d₃ is the deuterium labeled Orphenadrine[1].

HY-B1126

Orphenadrine hydrochloride	iGluR	Neurological Disease Cancer
Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-B1126S

Orphenadrine-d3 hydrochloride	iGluR	Neurological Disease
Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride[1]. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[2][3].

HY-B0369AS

Orphenadrine-d3 citrate	Isotope-Labeled Compounds iGluR	Neurological Disease
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-B0369AR

Orphenadrine citrate (Standard)	iGluR	Neurological Disease
Orphenadrine (citrate) (Standard) is the analytical standard of Orphenadrine (citrate). This product is intended for research and analytical applications. Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-144142S

Orphenadrine impurity 6-d3 hydrochloride	Drug Metabolite Isotope-Labeled Compounds	Others
Orphenadrine impurity 6-d₃ (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride[1].

Cat. No.	Product Name	Chemical Structure

HY-143861S

Orphenadrine-d3
Orphenadrine-d₃ is the deuterium labeled Orphenadrine[1].

HY-B1126S

Orphenadrine-d3 hydrochloride
Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride[1]. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[2][3].

Orphenadrine-d3 hydrochloride

Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride[1]. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[2][3].

HY-B0369AS

Orphenadrine-d3 citrate
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-144142S

Orphenadrine impurity 6-d3 hydrochloride
Orphenadrine impurity 6-d₃ (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride[1].

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