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α,β-unsaturated

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (2) Bacterial (2) Biochemical Assay Reagents (3) Endogenous Metabolite (2) Fungal (1) Isotope-Labeled Compounds (3) Microtubule/Tubulin (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (3) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0932

Isophorone	Biochemical Assay Reagents	Others
Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-Y1147

Diethyl maleate Maleic acid diethyl ester	Biochemical Assay Reagents	Others
Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells .

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Others	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .

HY-Y0932S

Isophorone-d5	Isotope-Labeled Compounds	Others
Isophorone-d₅ is the deuterium labeled Isophorone. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers[1].

HY-N10391

(-)-Cleistenolide Cleistenolide	Bacterial	Infection Cancer
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity .

HY-Y0932S1

Isophorone-d8	Isotope-Labeled Compounds	Others
Isophorone-d₈ is the deuterium labeled Isophorone[1]. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers[2].

HY-Y0932R

Isophorone (Standard)	Biochemical Assay Reagents	Others
Isophorone (Standard) is the analytical standard of Isophorone. This product is intended for research and analytical applications. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-120893

trans-4,5-Epoxy-(E)-2-decenal	Others	Others
trans-4,5-Epoxy-(E)-2-decenal is an oxygenated α,β-unsaturated aldehyde found in mammalian blood that gives blood its characteristic metallic odor. It is used by predators to locate blood or prey .

HY-N7860

Δ2-cis Eicosenoic acid	Others	Infection
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats. Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.

HY-126637

Marasmic acid	Bacterial Fungal	Infection
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

HY-116446

Pironetin	Microtubule/Tubulin	Cancer
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity .

HY-113466

4-Hydroxynonenal 5+ Cited Publications 4-HNE	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-113466S

4-Hydroxynonenal-d3 4-HNE-d₃	Isotope-Labeled Compounds Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

Cat. No.	Product Name	Type

HY-Y1147

Diethyl maleate Maleic acid diethyl ester	Biochemical Assay Reagents
Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0932

Isophorone	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Biochemical Assay Reagents
Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-113466

4-Hydroxynonenal 5+ Cited Publications 4-HNE	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-N10391

(-)-Cleistenolide Cleistenolide	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Annonaceae Disease Research Fields Cleistochlamys kirkii Oliver Cancer	Bacterial
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity .

HY-Y0932R

Isophorone (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Biochemical Assay Reagents
Isophorone (Standard) is the analytical standard of Isophorone. This product is intended for research and analytical applications. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-N7860

Δ2-cis Eicosenoic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Others
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats. Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.

HY-126637

Marasmic acid	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Fungal
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

Cat. No.	Product Name	Chemical Structure

HY-113466S

4-Hydroxynonenal-d3
4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

4-Hydroxynonenal-d3

4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

HY-Y0932S

Isophorone-d5
Isophorone-d₅ is the deuterium labeled Isophorone. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers[1].

HY-Y0932S1

Isophorone-d8
Isophorone-d₈ is the deuterium labeled Isophorone[1]. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers[2].

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α,β-unsaturated

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products