2. Anti-infection
  3. Fungal Bacterial
  4. Marasmic acid

Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

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Marasmic acid Chemical Structure

Marasmic acid Chemical Structure

CAS No. : 2212-99-9

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Marasmic acid Related Antibodies

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Description

Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

Molecular Weight

262.30

Formula

C15H18O4
CAS No.
SMILES

O=CC1=C[C@]2([H])CC(C)(C)C[C@]2([H])[C@]34C(O[C@H](O)[C@@]31C4)=O
Structure Classification
Initial Source

Marasmius conigenus
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Marasmic acid Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Marasmic acid2212-99-9FungalBacterialInhibitorinhibitorinhibit

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