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AChE/BChE-IN-25

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168731
    AChE/BChE-IN-25

    		Cholinesterase (ChE) Neurological Disease
    AChE/BChE-IN-25 (Compound 6e) is the orally active inhibitor for hAChE and eqBChE with IC50 of 7.9 nM and 0.79 nM. AChE/BChE-IN-25 exhibits antioxidant activity, that scavenges free radical with IC50 of 22.91 μM. AChE/BChE-IN-25 exhibits neuroprotective effects by reducing mitochondrial and cellular oxidative stress in the Drosophila Alzheimer's disease model. AChE/BChE-IN-25 ameliorates Scopolamine (HY-N0296)-induced spatial and cognitive memory impairment in mouse model .
    AChE/BChE-IN-25
  • HY-157520
    BChE-IN-25

    		Cholinesterase (ChE) Others
    BChE-IN-25 (compound 4I) is a selective BChE inhibitor (IC50: 3.77μM), which is 22 times more selective for BChE than AChE .
    BChE-IN-25

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