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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Burkitt lymphoma cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BCL6 (1) Btk (2) Glucocorticoid Receptor (1) PROTACs (1)
By Research Areas:	Cancer (5) Endocrinology (1)

5

Inhibitors & Agonists

1

Inhibitory Antibodies

Targets Recommended: Anaplastic lymphoma kinase (ALK) BCL6 Itk TOPK MALT1 NAMPT ALCAM/CD166 GDNF Receptor VISTA Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

JS25	Btk	Cancer
JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC₅₀ value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitt’s lymphoma. JS25 effectively crosses the blood-brain barrier .

ARV-393	PROTACs BCL6	Cancer
ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC₅₀ and GI₅₀ values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.

(S)-Pomalidomide (S)-CC-4047	Others	Cancer
(S)-Pomalidomide ((S)-CC-4047) is an angiogenesis-inhibiting drug with growth-inhibitory activity against B-cell tumors. (S)-Pomalidomide can induce complete tumor regression in BurK_itt lymphoma cells. (S)-Pomalidomide serves as an immunomodulator with potential applications in inhibiting hematological malignancies .

BTK-IN-28	Btk	Cancer
BTK-IN-28 (compound PID-4) is a potent BTK inhibitor with anticancer activity. BTK-IN-28 has inhibitory effects on BTK and downstream signaling cascades and selectively inhibits Burkitt lymphoma RAMOS proliferation. BTK-IN-28 has no significant cytotoxicity towards non-tumor cells .

RU-25055	Glucocorticoid Receptor	Endocrinology
RU-25055 is a potent antiglucocorticoid. RU-25055 inhibits early antigen production of the EpsteinBarr virus (EBV) by dexamethasone .

Cat. No.	Product Name	Target	Research Area

Vorsetuzumab	Inhibitory Antibodies	Cancer
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma .

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