2. Search Result
Search Result
Results for "

CBR1 inhibitor

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155587
    Hydroxy-PP

    		Others Cancer
    Hydroxy-PP is a potent CBR1 inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM .
    Hydroxy-PP
  • HY-13930
    Miquelianin
    3 Publications Verification

    Quercetin 3-O-glucuronide; Quercetin 3-glucuronide

    		 Endogenous Metabolite Cancer
    Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.
    Miquelianin
  • HY-121710
    MonoHER

    7-Monohydroxyethylrutoside

    		 Others Cardiovascular Disease
    MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner .
    MonoHER
  • HY-157448
    CBR1-IN-6

    		Apoptosis Cancer
    CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities .
    CBR1-IN-6
  • HY-157450
    YF-Mo1

    		Apoptosis Cancer
    YF-Mo1 (compound 9) is a CBR1 inhibitor with an IC50 value of 1.1 μM .
    YF-Mo1
  • HY-157451
    CBR1-IN-7

    		Others Cancer
    CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC50=8 μM). CBR1-IN-7 can be used in cancer research .
    CBR1-IN-7
  • HY-157447
    CBR1-IN-4

    		Others Cancer
    CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research .
    CBR1-IN-4
  • HY-157449
    CBR1-IN-5

    		Others Cancer
    CBR1-IN-5 (compound 13o) is a potent inhibitor of CBR1 with an IC50 of 0.1 μM .
    CBR1-IN-5
  • HY-157445
    CBR1-IN-3

    		Others Metabolic Disease
    CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC50 value of 0.034 μM .
    CBR1-IN-3
  • HY-157452
    (8S)-Methyl zearalenone

    		Others Cancer
    (8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC50 of 0.21 μM .
    (8S)-Methyl zearalenone
  • HY-13930R
    Miquelianin (Standard)

    		Endogenous Metabolite Cancer
    Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.
    Miquelianin (Standard)
  • HY-156694
    Hydroxy-PP-Me

    		Apoptosis Cancer
    Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As2O3-induced apoptotic cell death compared with As2O3 alone .
    Hydroxy-PP-Me
  • HY-N0148
    Rutin
    Maximum Cited Publications
    11 Publications Verification

    Rutoside; Quercetin 3-O-rutinoside

    		 Amyloid-β Autophagy Apoptosis Endogenous Metabolite Inflammation/Immunology Cancer
    Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
    Rutin
  • HY-N0148R
    Rutin (Standard)

    		Amyloid-β Autophagy Apoptosis Endogenous Metabolite Inflammation/Immunology Cancer
    Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
    Rutin (Standard)
  • HY-N2609
    7,4'-Dihydroxyflavone
    1 Publications Verification

    		 COX CCR NF-κB Inflammation/Immunology Endocrinology
    7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
    7,4'-Dihydroxyflavone

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: