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CFT 8634

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145925B
    CFT8634

    		PROTACs Epigenetic Reader Domain Cancer
    CFT8634 (compound 174) is an oral activity degrader targeting PROTAC BRD9. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991)) .
    CFT8634
  • HY-145925C
    (S,R)-CFT8634

    		PROTACs Epigenetic Reader Domain Cancer
    (S,R)-CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S,R)-CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S,R)-CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 (HY-169988), an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1-(3,3-Difluoro-4-piperidinyl)piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990) .
    (S,R)-CFT8634
  • HY-169989
    CRBN ligand-11

    		Ligands for E3 Ligase Cancer
    CRBN ligand-11 is the E3 ubiquitin ligase ligand for CFT8634 (HY-145925B). CRBN ligand-11 can be used for the synthesis of PROTACs .
    CRBN ligand-11
  • HY-169988
    BRD9 ligand-5

    		Ligands for Target Protein for PROTAC Cancer
    BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B) .
    BRD9 ligand-5

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