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Isoforms Recommended:	CXCR7

Results for "

CXCR7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arrestin (2) CXCR (16) Fluorescent Dye (1) HIV (5) Isotope-Labeled Compounds (1) Opioid Receptor (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Endocrinology (6) Infection (5) Inflammation/Immunology (8) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139643

CXCR7 antagonist-1	CXCR	Inflammation/Immunology Cancer
CXCR7 antagonist-1 is a *CXCR7* antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128) .

HY-139643A

CXCR7 antagonist-1 hydrochloride	CXCR	Inflammation/Immunology Cancer
CXCR7 antagonist-1 hydrochloride is a *CXCR7* antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128) .

HY-112154

CXCR7 modulator 2	CXCR	Cardiovascular Disease Endocrinology
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a K_i of 13 nM.

HY-107987

CXCR7 modulator 1	CXCR	Endocrinology
CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid *CXCR7* modulator, with a K_i of 9 nM .

HY-110318

VUF11207 fumarate 2 Publications Verification	CXCR	Inflammation/Immunology Cancer
VUF11207 fumarate is a *CXCR7* agonist that binds specifically to *CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK* phosphorylation .

HY-P1102

TC14012 2 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic *CXCR4* antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent *CXCR7* agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity .

HY-100677

VUF11207	CXCR	Endocrinology
VUF11207 (Compound 29) is a *CXCR7* agonist and a high-potency *CXCR7* (pK_i of 8.1) ligand that induces recruitment of β-arrestin2 (pEC₅₀ of 8.8) and subsequent internalization (pEC₅₀ of 7.9) of *CXCR7* .

HY-167851

CCX662	CXCR	Cancer
CCX662 is *CXCR7* antagonist. CCX662 inhibits the binding of 125I-CXCL12 to CXCR7, with an IC₅₀ of 9 nM. CCX662 can be used in anti-cancer research .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic *CXCR4* antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent *CXCR7* agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity .

HY-W019787

BAM-12P	Opioid Receptor CXCR	Neurological Disease
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC₅₀ of 101 nM and a pEC₅₀ of 6.99. BAM-12P is a ligand for *CXCR7* with an EC₅₀ of 175 nM .

HY-142617

ACT-1004-1239	CXCR	Neurological Disease Inflammation/Immunology Cancer
ACT-1004-1239 is a potent, selective, orally active *CXCR7* antagonist with an IC₅₀ value of 3.2 nM .

HY-10046

Plerixafor Maximum Cited Publications 67 Publications Verification AMD 3100; JM3100; SID791	CXCR HIV	Infection Inflammation/Immunology Endocrinology Cancer
Plerixafor (AMD 3100) is a selective *CXCR4* antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM ^[7].

HY-10046R

Plerixafor (Standard)	CXCR HIV	Infection Inflammation/Immunology Endocrinology Cancer
Plerixafor (Standard) is the analytical standard of Plerixafor. This product is intended for research and analytical applications. Plerixafor (AMD 3100) is a selective *CXCR4* antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM ^[7].

HY-10046S

Plerixafor-d4	Isotope-Labeled Compounds CXCR HIV	Infection Inflammation/Immunology Endocrinology Cancer
Plerixafor-d₄ is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM[1][2][3][4][7].

HY-P1682

Balixafortide POL6326	CXCR Arrestin	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic *CXCR4* antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for *CXCR4* than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P1682A

Balixafortide TFA 1 Publications Verification POL6326 TFA	CXCR Arrestin	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic *CXCR4* antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for *CXCR4* than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-D2201

Fluorescent ACKR3 antagonist 1	Fluorescent Dye	Cancer
Fluorescent ACKR3 antagonist 1(compound 18a) is a atypical chemokine receptor 3 antagonist .

Fluorescent ACKR3 antagonist 1	Fluorescent Dyes/Probes
Fluorescent ACKR3 antagonist 1(compound 18a) is a atypical chemokine receptor 3 antagonist .

Cat. No.	Product Name	Target	Research Area

HY-P1102

TC14012 2 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic *CXCR4* antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent *CXCR7* agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity .

HY-P1682A

Balixafortide TFA 1 Publications Verification POL6326 TFA	CXCR Arrestin	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic *CXCR4* antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for *CXCR4* than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic *CXCR4* antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent *CXCR7* agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity .

HY-W019787

BAM-12P	Opioid Receptor CXCR	Neurological Disease
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC₅₀ of 101 nM and a pEC₅₀ of 6.99. BAM-12P is a ligand for *CXCR7* with an EC₅₀ of 175 nM .

HY-P10333

LIH383	Peptides	Neurological Disease Inflammation/Immunology
LIH383 is an agonist of ACKR3 (CXCR7) (EC₅₀=0.61 nM). LIH383 efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling .

HY-P1682

Balixafortide POL6326	CXCR Arrestin	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic *CXCR4* antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for *CXCR4* than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

Recombinant Proteins Recommended:

CXCR7

Cat. No.	Compare	Product Name	Species	Source

HY-P700537

	ACKR3 Protein, Human (His-SUMO) RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159	Human	E. coli
	ACKR3 is an atypical chemokine receptor that precisely controls chemokine levels and localization through high-affinity binding, operating independently of ligand-driven signaling. It acts as an interceptor, internalization receptor, and chemokine scavenger for CXCL11 and CXCL12/SDF1, inducing β-arrestin recruitment, ligand internalization, and MAPK pathway activation. ACKR3 Protein, Human (His-SUMO) is the recombinant human-derived ACKR3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of ACKR3 Protein, Human (His-SUMO) is 40 a.a., with molecular weight of 20.5 kDa.

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HY-10046S

Plerixafor-d4
Plerixafor-d₄ is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM[1][2][3][4][7].

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HY-P83212

	RDC1 Antibody (YA2957) RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159	WB	Human, Mouse, Rat
	RDC1 Antibody (YA2957) is a biotin-conjugated non-conjugated IgG antibody, targeting RDC1, with a predicted molecular weight of 41 kDa (observed band size: 41 kDa). RDC1 Antibody (YA2957) can be used for WB experiment in human, mouse, rat background.

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