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E3 Ligase Ligand-linker Conjugate 142

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169990
    E3 Ligase Ligand-linker Conjugate 142

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 142 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of CFT8634 (HY-145925B) .
    E3 Ligase Ligand-linker Conjugate 142
  • HY-145925C
    (S,R)-CFT8634

    		PROTACs Epigenetic Reader Domain Cancer
    (S,R)-CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S,R)-CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S,R)-CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 (HY-169988), an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1-(3,3-Difluoro-4-piperidinyl)piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990) .
    (S,R)-CFT8634

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