GAT-1

By Targets:	GABA Receptor (12) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1) Neurological Disease (10)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100228A

SKF89976A hydrochloride d,l-SKF89976A hydrochloride	GABA Receptor	Neurological Disease
SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-124285

ATPCA hydrochloride	GABA Receptor	Others
ATPCA hydrochloride is a selective radioactive substrate for *BGT1* over GAT1/GAT3 ^[1].

HY-103534

CI-966 hydrochloride	GABA Receptor	Neurological Disease
CI-966 hydrochloride is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter *GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively. CI-966 hydrochloride shows more than 200-fold selectivity over GAT-2, GAT*-3, and BGT-3. CI-966 hydrochloride exhibits anticonvulsant and neuroprotective activities ^[1] .

HY-100809

Guvacine hydrochloride	GABA Receptor	Neurological Disease
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC₅₀s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

HY-103506

NNC-711 NO-711 hydrochloride	GABA Receptor	Neurological Disease
NNC-711 is a potent and selective inhibitor of GAT-1 ( GABA transporter 1) with an IC₅₀ of 40 nM for hGAT-1. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity ^[1] .

HY-N2482

Guvacine	GABA Receptor	Neurological Disease
Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC₅₀ values of 39 μM, 58 μM and 378 μM, respectively ^[1].

HY-N2482A

Guvacine hydrobromide	GABA Receptor	Neurological Disease
Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC₅₀ values of 39 μM, 58 μM and 378 μM, respectively ^[1].

HY-100228

SKF 89976A	GABA Receptor	Neurological Disease
SKF89976A is a selective GABA transporter (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-123240

CI-966	GABA Receptor	Neurological Disease
CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter *GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively. CI-966 shows more than 200-fold selectivity over GAT-2, GAT*-3, and BGT-3. CI-966 exhibits anticonvulsant and neuroprotective activities ^[1] .

HY-155238

E2730	GABA Receptor	Neurological Disease
E2730 is a noncompetitive but selective inhibitor of gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with orally available and antiepileptic activity. E2730-mediated GAT1 inhibition is positively correlated with environmental GABA levels and selectively inhibits GAT1-mediated GABA uptake. E2730 (5-50 mg/kg; po) in rat amygdala ignition model, and in mouse cornea ignition (5-50 mg/kg), drug resistance 6Hz-44mA has demonstrated in vivo efficacy in models of psychomotor epilepsy (5-50 mg/kg), fragile X syndrome (2.5-300 mg/kg), and Dravet syndrome (10 mg/kg, 20 mg/kg) ^[1].

HY-RS01307

B3GAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
B3GAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for B3GAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

B3GAT1 Human Pre-designed siRNA Set A B3GAT1 Human Pre-designed siRNA Set A

HY-RS01326

B4GAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
B4GAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for B4GAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

B4GAT1 Human Pre-designed siRNA Set A B4GAT1 Human Pre-designed siRNA Set A

HY-118207

LU-32-176B	GABA Receptor	Cancer
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and *mGAT1* with the IC₅₀ values of 2μM, 1μM, 4μM, respectively ^[1] .

HY-118931

EF-1502	GABA Receptor	Neurological Disease
EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy ^[1].

Cat. No.	Product Name	Type

HY-E70179

β-1,4-Glucuronyltransferase 1 EC 2.4.1.149; B4GAT1; β3GNTI	Enzyme Substrates
beta-1,4-Glucuronyltransferase 1 is a glucosyltransferase. beta-1,4-Glucuronyltransferase 1 transfers glucuronic acid towards both α and β anomers of xylose ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100809

Guvacine hydrochloride	Alkaloids Structural Classification Neurological Disease Classification of Application Fields Areca catechu L. Source classification Pyridine Alkaloids Palmae Plants Disease Research Fields	GABA Receptor
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC₅₀s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

HY-N2482

Guvacine	Alkaloids Structural Classification Areca catechu L. Source classification Pyridine Alkaloids Plants Palmae	GABA Receptor
Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC₅₀ values of 39 μM, 58 μM and 378 μM, respectively ^[1].

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P703208

	GAT1 Protein, Human (HEK293) GABATR; GABT1; GAT1	Human	HEK293
	GAT1 Protein, Human (HEK293) is the recombinant human-derived GAT1, expressed by HEK293 , with tag Free labeled tag. The total length of GAT1 Protein, Human (HEK293) is 599 a.a.,

HY-P70114

	B3GAT1 Protein, Human (HEK293, His) rHuGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1/B3GAT1, His; B3GAT1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); CD57; GlcAT-P; HNK1; NK1; NK-1	Human	HEK293
	B3GAT1 Protein is pivotal in L2/HNK-1 carbohydrate epitope biosynthesis on glycoproteins and glycosaminoglycan biosynthesis.Catalyzing substrates like ASOR and asialo-fetuin, its enzymatic function depends on sphingomyelin presence, with stearoyl-sphingomyelin being the most effective.Notably, it exclusively acts on saturated fatty acids in sphingomyelin, showing no reactivity with unsaturated fatty acids, regardless of acyl group length.B3GAT1 Protein, Human (HEK293, His) is the recombinant human-derived B3GAT1 protein, expressed by HEK293 , with N-6*His labeled tag.

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HY-P82050

	GABA Transporter 1 Antibody (YA1795) GABATHG; GABATR; GABT1; GAT1; Slc6a1	WB	Human, Mouse, Rat
	GABA Transporter 1 Antibody (YA1795) is a biotin-conjugated non-conjugated IgG antibody, targeting GABA Transporter 1, with a predicted molecular weight of 67 kDa (observed band size: 67 kDa). GABA Transporter 1 Antibody (YA1795) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS01307

B3GAT1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
B3GAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for B3GAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01326

B4GAT1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
B4GAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for B4GAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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