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Results for "

GSDMD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (1) Aldehyde Dehydrogenase (ALDH) (2) Antibiotic (1) Apoptosis (6) Autophagy (1) Bacterial (1) Caspase (2) Cuproptosis (2) Deubiquitinase (1) Ferroptosis (1) IKK (1) Interleukin Related (3) NF-κB (2) NOD-like Receptor (NLR) (5) P2Y Receptor (1) Pyroptosis (9) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1) Sodium Channel (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (7) Metabolic Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152670

JC2-11 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 .

HY-111675

Ac-FLTD-CMK 5+ Cited Publications	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC₅₀ of 46.7 nM), caspases-4 (IC₅₀ of 1.49 μM), caspases-5 (IC₅₀ of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3 .

HY-111674

LDC7559 5+ Cited Publications	Pyroptosis	Inflammation/Immunology
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .

HY-127019

Nigericin 115+ Cited Publications	Sodium Channel NOD-like Receptor (NLR) Bacterial Apoptosis Antibiotic Pyroptosis Wnt β-catenin	Infection Cancer
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-N0816

Polyphyllin VI 1 Publications Verification	Apoptosis Pyroptosis	Cancer
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer .

HY-B0240

Disulfiram 60+ Cited Publications Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-RS05857

GSDMD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GSDMD Human Pre-designed siRNA Set A contains three designed siRNAs for GSDMD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GSDMD Human Pre-designed siRNA Set A GSDMD Human Pre-designed siRNA Set A

HY-161332

Antitumor agent-143	Ferroptosis Pyroptosis Apoptosis Reactive Oxygen Species	Cancer
Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis by a ROS-mediated mitochondrial dysfunction pathway and *GSDMD*-mediated pyroptosis .

HY-169018

CIB-1476	Caspase NOD-like Receptor (NLR) NF-κB Interleukin Related Pyroptosis	Inflammation/Immunology
CIB-1476 is a caspase-1 inhibitor. CIB-1476 can exert lasting anti-inflammatory effects by inhibiting IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis induced by the NLRP3 inflammasome. CIB-1476 can reduce joint swelling in models of arthritis in mice .

HY-156374

D359-0396	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice .

HY-B0240R

Disulfiram (Standard)	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu ²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells ^[1-6].

HY-13453

BAY 11-7082 Maximum Cited Publications 306 Publications Verification BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

HY-161727

P2Y14R antagonist 1	P2Y Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC₅₀ of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis .

Polyphyllin VI 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81230

	GSDMD Antibody DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; Gasdermin D; Gasdermin domain containing 1; Gasdermin domain containing protein 1; Gasdermin domain-containing protein 1; Gasdermin-D; GasderminD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1; Gasdermin-D, N-terminal; GSDMD-NT; hGSDMD-NTD; Gasdermin-D, C-terminal; GSDMD-CT; hGSDMD-CTD.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human
	GSDMD Antibody is an unconjugated, approximately 53 kDa, rabbit-derived, anti-GSDMD polyclonal antibody. GSDMD Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, and predicted: mouse, rat background without labeling.

HY-P83706

	GSDMD Antibody (YA3443) DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; Gasdermin D; Gasdermin domain containing 1; Gasdermin domain containing protein 1; Gasdermin domain-containing protein 1; Gasdermin-D; GasderminD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1; Gasdermin-D, N-terminal; GSDMD-NT; hGSDMD-NTD; Gasdermin-D, C-terminal; GSDMD-CT; hGSDMD-CTD.	WB	Human
	GSDMD Antibody is an unconjugated, approximately 53 kDa, rabbit-derived, anti-GSDMD monoclonal antibody. GSDMD Antibody can be used for: WB expriments in human background without labeling.

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GSDMD Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GSDMD Human Pre-designed siRNA Set A contains three designed siRNAs for GSDMD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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