2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) AIM2
  4. JC2-11

JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1.

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JC2-11 Chemical Structure

JC2-11 Chemical Structure

CAS No. : 937820-89-8

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Based on 1 publication(s) in Google Scholar

JC2-11 Related Antibodies

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1 Publications Citing Use of MCE JC2-11

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NLRP3 NLRP1 NOD1 NOD2

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Description

JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].

IC50 & Target[1]

NLRP3 inflammasome

 

In Vivo

JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibits the release of caspase-1 (p20) and IL-1β in non-canonical (NC) inflammatory bodies, and weakens the activation of NC inflammatory bodies of C57BL/6 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (8 weeks, female)[1].
Dosage: 250 μg/mouse.
Administration: Intraperitoneal injection; single dose.
Result: Exhibited inhibitory effect on NC inflammatory body.
Molecular Weight

302.30

Formula

C17H15FO4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

COC1=CC(/C=C/C(C2=CC(F)=C(C=C2)OC)=O)=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (330.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3080 mL 16.5399 mL 33.0797 mL
5 mM 0.6616 mL 3.3080 mL 6.6159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3080 mL 16.5399 mL 33.0797 mL 82.6993 mL
5 mM 0.6616 mL 3.3080 mL 6.6159 mL 16.5399 mL
10 mM 0.3308 mL 1.6540 mL 3.3080 mL 8.2699 mL
15 mM 0.2205 mL 1.1027 mL 2.2053 mL 5.5133 mL
20 mM 0.1654 mL 0.8270 mL 1.6540 mL 4.1350 mL
25 mM 0.1323 mL 0.6616 mL 1.3232 mL 3.3080 mL
30 mM 0.1103 mL 0.5513 mL 1.1027 mL 2.7566 mL
40 mM 0.0827 mL 0.4135 mL 0.8270 mL 2.0675 mL
50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6540 mL
60 mM 0.0551 mL 0.2757 mL 0.5513 mL 1.3783 mL
80 mM 0.0413 mL 0.2067 mL 0.4135 mL 1.0337 mL
100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8270 mL
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JC2-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JC2-11937820-89-8NOD-like Receptor (NLR)AIM2Absent in melanoma 2Interferon-inducible protein AIM2PYHINMiceCaspase-1IL-1βGSDMDLDHInhibitorinhibitorinhibit

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