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Glucagon receptor antagonists-7

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128103
    Glucagon receptor antagonists-7

    		GCGR Adenylate Cyclase Metabolic Disease
    Glucagon receptor antagonists-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonists-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonists-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels .
    Glucagon receptor antagonists-7

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