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Pathways Recommended: PROTAC
Results for "

HDAC8 PROTAC

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-152147
    SZUH280

    		PROTACs HDAC Apoptosis DNA/RNA Synthesis Cancer
    SZUH280 is a potent and selective PROTAC HDAC8 degrader with a DC50 of 0.58 μM in A549 cells. SZUH280 induces cancer cell apoptosis. SZUH280 hampers DNA damage repair in cancer cells, promoting cellular radiosensitization .
    SZUH280
  • HY-163920
    PROTAC HDAC8 Degrader-1

    		PROTACs HDAC Cancer
    Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells .
    PROTAC HDAC8 Degrader-1
  • HY-168175
    PROTAC HDAC8 Degrader-2

    		PROTACs HDAC Cancer
    PROTAC HDAC8 Degrader-2 (compound 32a) is a degrader of HDAC8 with a DC50 of 8.9 nM and HDAC6 with a DC50 of 14.3 nM. PROTAC HDAC8 Degrader-2 is composed of PROTAC target protein ligand HDAC8 ligand 1 (HY-168176) (red part), E3 ligase ligand Thalidomide-4-OH (HY-103596) (blue part) and PROTAC Linker 1,5-Diaminopentane (HY-W540541) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C5-NH2 (HY-134986) .
    PROTAC HDAC8 Degrader-2
  • HY-163846
    HDAC8-IN-10

    		HDAC Cancer
    HDAC8-IN-10 (compound 15) is a potent inhibitor of HDAC8, with the IC50 of 7.6 nM. HDAC8-IN-10 is a HDAC8 target protein ligand that can be used to synthesize PROTAC YX862 (HY-163845) .
    HDAC8-IN-10
  • HY-168176
    HDAC8 ligand 1

    		PROTACs HDAC Cancer
    HDAC8 ligand 1 is a PROTAC target protein-ligand of PROTAC HDAC8 Degrader-2 (HY-168174) .
    HDAC8 ligand 1
  • HY-163921
    HDAC8-IN-11

    		Ligands for Target Protein for PROTAC Cancer
    HDAC8-IN-11 is a ligand for target protein for pROTAC.
    HDAC8-IN-11
  • HY-163845
    YX862

    		PROTACs HDAC Cancer
    YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells(Sturcture Note:(Blue: VHL E3 ligand (HY-112078), Black: linker；Pink: HDAC8 inhibitor (HY-163846)) .
    YX862

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