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Results for "

KHK

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

4

Inhibitory Antibodies

1

Recombinant Proteins

1

Click Chemistry

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103478
    KHK-IN-2

    		Ketohexokinase Metabolic Disease
    KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
    KHK-IN-2
  • HY-12841A
    KHK-IN-1 hydrochloride
    1 Publications Verification

    		 Ketohexokinase Metabolic Disease
    KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity .
    KHK-IN-1 hydrochloride
  • HY-149987
    LY3522348

    KHK-IN-3

    		 Ketohexokinase Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation .
    LY3522348
  • HY-17613
    Evocalcet
    1 Publications Verification

    KHK7580

    		 CaSR Metabolic Disease
    Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .
    Evocalcet
  • HY-149605
    KHK-IN-4

    		Ketohexokinase Metabolic Disease
    KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research .
    KHK-IN-4
  • HY-162982
    KHK-IN-6

    		Ketohexokinase Cancer
    KHK-IN-6 (compund 33) is a KHK inhibitor with IC50 of 0.6 nM .
    KHK-IN-6
  • HY-163886
    KHK-IN-5

    		Ketohexokinase Metabolic Disease
    KHK-IN-5 (Compound 18) is a KHK inhibitor. KHK-IN-5 can be used for the research of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and type 2 diabetes (T2DM) .
    KHK-IN-5
  • HY-12841
    KHK-IN-1

    		Ketohexokinase Metabolic Disease
    KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity .
    KHK-IN-1
  • HY-159123
    KHK-6

    		MAP4K Cancer
    KHK-6 is an inhibitor for serine/threonine kinase hematopoietic progenitor kinase 1 (HPK 1) with an IC50 of 20 nM. KHK-6 enhances CD3/CD28-induced cytokine production, enhances CD69, CD25 and HLA-DR markers on CD4+ and CD8+ T cells, and enhances T cell-mediated killing activity of SKOV3 and A549 cells .
    KHK-6
  • HY-RS07240
    KHK Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KHK Human Pre-designed siRNA Set A contains three designed siRNAs for KHK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KHK Human Pre-designed siRNA Set A
    KHK Human Pre-designed siRNA Set A
  • HY-P9925
    Brodalumab
    2 Publications Verification

    AMG 827; KHK4827

    		 Interleukin Related Inflammation/Immunology
    Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .
    Brodalumab
  • HY-17613R
    Evocalcet (Standard)

    		CaSR Metabolic Disease
    Evocalcet (Standard) is the analytical standard of Evocalcet. This product is intended for research and analytical applications. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .
    Evocalcet (Standard)

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