2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ketohexokinase

Ketohexokinase

KHK

 

Ketohexokinase Related Products (8):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12841A
    KHK-IN-1 hydrochloride
    		Inhibitor 98.47%
    KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity.
    KHK-IN-1 hydrochloride
  • HY-103478
    KHK-IN-2
    		Inhibitor 99.75%
    KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
    KHK-IN-2
  • HY-149987
    LY3522348
    		Inhibitor 99.31%
    KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation.
    LY3522348
  • HY-12841
    KHK-IN-1
    		Inhibitor
    KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity.
    KHK-IN-1
  • HY-161993
    BI-9787
    		Inhibitor
    BI-9787 is a zwitterionic inhibitior for ketohexokinase, with an IC50 of 12 and 12.8 nM for hKHK-A and hKHK-C. BI-9787 exhibits good metabolic stability in rat hepatocyte and good pharmacokinetic characteristics in rats.
    BI-9787
  • HY-149605
    KHK-IN-4
    		Inhibitor
    KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research.
    KHK-IN-4
  • HY-163886
    KHK-IN-5
    		Inhibitor
    KHK-IN-5 (Compound 18) is a KHK inhibitor. KHK-IN-5 can be used for the research of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and type 2 diabetes (T2DM).
    KHK-IN-5
  • HY-162982
    KHK-IN-6
    KHK-IN-6 (compund 33) is a KHK inhibitor with IC50 of 0.6 nM.
    KHK-IN-6