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Lenalidomide-C13-piperazine-Boc

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169377
    Lenalidomide-C13-piperazine-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Lenalidomide-C13-piperazine-Boc is a conjugate of the E3 ligase ligand and the linker, that can be used for synthesis of PROTAC degrader NC-R17 (HY-155075) .
    Lenalidomide-C13-piperazine-Boc
  • HY-155075
    NC-R17

    		PROTACs Glutathione Peroxidase Ferroptosis Cancer
    NC-R17 is a PROTAC-class, non-covalent GPX4 degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design . NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832); an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376). E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377); the active control for the target protein ligand is RSL3-4-Me (HY-169375).
    NC-R17

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