MetAP-2

Isoforms Recommended:	MetAP2

By Targets:	MetAP (11) AUTACs (2) Autophagy (2) AUTOTACs (1) Estrogen Receptor/ERR (1) p62 (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (6)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Targets Recommended: MetAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128147

MetAP-2-IN-6	MetAP	Cancer
MetAP-2-IN-6 is a *MetAP2* inhibitor. MetAP-2-IN-6 can be used for research in conditions mediated by angiogenesis .

HY-133016

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity ^[2].

HY-134183

AUTAC1	AUTACs Autophagy	Metabolic Disease Cancer
AUTAC1 is a *MetAP2*-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2 .

HY-P4344

Met-Gly-Pro-AMC	MetAP	Others
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .

HY-13731

PPI-2458	MetAP	Inflammation/Immunology Cancer
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research ^[2].

HY-120868

TP-004	MetAP	Metabolic Disease
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC₅₀ of 6 nM .

HY-133016A

(R)-M8891	MetAP	Others
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .

HY-RS08350

METAP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METAP2 Human Pre-designed siRNA Set A METAP2 Human Pre-designed siRNA Set A

HY-109188

Relzomostat	MetAP	Metabolic Disease
Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions .

HY-14811

Beloranib ZGN-440; CKD-732 free base	MetAP	Metabolic Disease
Beloranib is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes ^[2] .

HY-150409

TSPO ligand-2	AUTACs	Cancer
TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells .

HY-161742

Fumagilin-105	AUTOTACs Estrogen Receptor/ERR Autophagy p62	Cancer
Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC₅₀ values of 0.7 μM for MetAP2 in HEK293 cells .

HY-158006

SDX-7539	MetAP	Cancer
SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC₅₀ of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice .

HY-114196

Aclimostat ZGN-1061	MetAP	Metabolic Disease
Aclimostat (ZGN-1061) is a potent inhibitor of the *MetAP2* enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells .

HY-14811A

Beloranib hemioxalate ZGN-440 hemioxalate; ZGN-433 hemioxalate; CDK732 hemioxalate	MetAP	Metabolic Disease
Beloranib (ZGN-440; ZGN-433) hemioxalate is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib hemioxalate decreases food intake, body weight, fat mass, and the size of adipocytes. Beloranib hemioxalate plays an important role in anti-obesity activity or obesity research ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P4344

Met-Gly-Pro-AMC	MetAP	Others
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13731

PPI-2458	Classification of Application Fields Disease Research Fields Cancer	MetAP
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research ^[2].

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70364

	METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His) rHuMethionine aminopeptidase 2/MetAP2, His; Methionine aminopeptidase 2; MAP 2; MetAP 2; p67; p67eIF2; Peptidase M; MetAP2; MAP2	Human	Sf9 insect cells
	METAP2/Methionine aminopeptidase 2 protein removes N-terminal methionine from nascent proteins. It preferentially cleaves when the second residue is small and uncharged. METAP2 has higher catalytic activity for Met-Val peptides than METAP1, suggesting its role in processing Met-Val and Met-Thr sequences in vivo. It also protects EIF2S1 from phosphorylation by inhibitory kinases, regulating protein synthesis. METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His) is the recombinant human-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells , with N-6*His labeled tag.

HY-P75925

	METAP2/Methionine aminopeptidase 2 Protein, Mouse (sf9, His) Methionine aminopeptidase 2; MAP 2; p67eIF2; Peptidase M; Mnpep	Mouse	Sf9 insect cells
	METAP2, also known as methionine aminopeptidase 2, plays a critical role in protein synthesis by co-translationally removing N-terminal methionine from nascent proteins. This enzymatic activity is particularly pronounced when the second residue in the primary sequence is small and uncharged (including residues such as Ala, Cys, Gly, Pro, Ser, Thr, or Val). METAP2/Methionine aminopeptidase 2 Protein, Mouse (sf9, His) is the recombinant mouse-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of METAP2/Methionine aminopeptidase 2 Protein, Mouse (sf9, His) is 477 a.a., with molecular weight of ~60 kDa.

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Cat. No.	Product Name		Classification

HY-RS08350

METAP2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
METAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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MetAP-2

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