2. PROTAC Vitamin D Related/Nuclear Receptor Autophagy
  3. AUTOTACs Estrogen Receptor/ERR Autophagy p62
  4. Fumagilin-105

Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC50 values of 0.7 μM for MetAP2 in HEK293 cells.

For research use only. We do not sell to patients.

Fumagilin-105 Chemical Structure

Fumagilin-105 Chemical Structure

CAS No. : 2410081-58-0

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Based on 1 publication(s) in Google Scholar

Fumagilin-105 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC50 values of 0.7 μM for MetAP2 in HEK293 cells[1].

Molecular Weight

784.98

Formula

C46H60N2O9
CAS No.
Appearance

Solid

Color

Colorless to off-white

SMILES

O=C(/C=C/C=C/C=C/C=C/C(OC1C(OC)C(C2(C)OC2C/C=C(C)\C)C3(OC3)CC1)=O)NCCOCCOCCNCC4=CC(OCC5=CC=CC=C5)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 63 mg/mL (80.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2739 mL 6.3696 mL 12.7392 mL
5 mM 0.2548 mL 1.2739 mL 2.5478 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2739 mL 6.3696 mL 12.7392 mL 31.8479 mL
5 mM 0.2548 mL 1.2739 mL 2.5478 mL 6.3696 mL
10 mM 0.1274 mL 0.6370 mL 1.2739 mL 3.1848 mL
15 mM 0.0849 mL 0.4246 mL 0.8493 mL 2.1232 mL
20 mM 0.0637 mL 0.3185 mL 0.6370 mL 1.5924 mL
25 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2739 mL
30 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0616 mL
40 mM 0.0318 mL 0.1592 mL 0.3185 mL 0.7962 mL
50 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6370 mL
60 mM 0.0212 mL 0.1062 mL 0.2123 mL 0.5308 mL
80 mM 0.0159 mL 0.0796 mL 0.1592 mL 0.3981 mL
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Fumagilin-105 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fumagilin-1052410081-58-0Fumagilin105Fumagilin 105AUTOTACsEstrogen Receptor/ERRAutophagyp62AUTOphagy-TArgeting ChimerasSequestosome-1SQSTM1AUTOTACp62 self-oligomerizationMetAP2Inhibitorinhibitorinhibit

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