TP-004

Cat. No.: HY-120868 Purity: 98.89%: FAQs
Data Sheet SDS COA Handling Instructions

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TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC₅₀ of 6 nM.

For research use only. We do not sell to patients.

TP-004 Chemical Structure

CAS No. : 1454299-21-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 396	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 396	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC₅₀ of 6 nM^[1].

IC₅₀ & Target

IC50: 6 nM (MetAP2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	EC₅₀	0.015 μM Compound: 38	Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method	[PMID: 27155900]
Sf9	IC₅₀	0.005 μM Compound: 38	Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured for 10 to 30 mins by fluorescence plate reader analysis Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured for 10 to 30 mins by fluorescence plate reader analysis	[PMID: 27155900]

Molecular Weight

363.34

Formula

C₁₇H₁₆F₃N₅O

CAS No.

1454299-21-8

Appearance

Solid

Color

Light yellow to khaki

SMILES

O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (688.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7522 mL	13.7612 mL	27.5224 mL
5 mM	0.5504 mL	2.7522 mL	5.5045 mL
10 mM	0.2752 mL	1.3761 mL	2.7522 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.89%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26(12), 2774–2778.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7522 mL	13.7612 mL	27.5224 mL	68.8061 mL
	5 mM	0.5504 mL	2.7522 mL	5.5045 mL	13.7612 mL
	10 mM	0.2752 mL	1.3761 mL	2.7522 mL	6.8806 mL
	15 mM	0.1835 mL	0.9174 mL	1.8348 mL	4.5871 mL
	20 mM	0.1376 mL	0.6881 mL	1.3761 mL	3.4403 mL
	25 mM	0.1101 mL	0.5504 mL	1.1009 mL	2.7522 mL
	30 mM	0.0917 mL	0.4587 mL	0.9174 mL	2.2935 mL
	40 mM	0.0688 mL	0.3440 mL	0.6881 mL	1.7202 mL
	50 mM	0.0550 mL	0.2752 mL	0.5504 mL	1.3761 mL
	60 mM	0.0459 mL	0.2294 mL	0.4587 mL	1.1468 mL
	80 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8601 mL
	100 mM	0.0275 mL	0.1376 mL	0.2752 mL	0.6881 mL

TP-004 Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-0041454299-21-8TP004TP 004MetAPMethionine AminopeptidasemethionineaminopeptidaseMetAP2Inhibitorinhibitorinhibit

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TP-004

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Complete Stock Solution Preparation Table

TP-004 Related Classifications

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