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Monophenolase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Endogenous Metabolite (3) Fungal (1) Isotope-Labeled Compounds (1) NF-κB (1) Sirtuin (1) Tyrosinase (8)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1193

Sulfuretin	NF-κB	Inflammation/Immunology
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis . Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC₅₀ of 13.64 μM .

HY-W016867

4-Chlorosalicylic acid	Fungal Bacterial	Infection
4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits *monophenolase* and diphenolase activity with IC₅₀s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.

HY-N3200

Neorauflavane	Tyrosinase	Cancer
Neorauflavane is a potent tyrosinase inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-W015616

Benzylacetone 4-Penylbutan-2-one	Tyrosinase	Metabolic Disease
Benzylacetone is an aromatic compound from agarwood . Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity， with IC₅₀s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively . Benzylacetone has appetite-enhancing and locomotor-reducing effects .

HY-N0192

Arbutin 1 Publications Verification β-Arbutin	Tyrosinase Endogenous Metabolite	Cancer
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i ^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-N2962

Broussonin C	Tyrosinase	Inflammation/Immunology
Broussonin C is a competitive inhibitor of Tyrosinase that can be isolated from Broussonetia kazinoki. Broussonin C inhibits *monophenolase* and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively .

HY-N0192S

Arbutin-d4 β-Arbutin-d₄	Isotope-Labeled Compounds Tyrosinase Endogenous Metabolite	Cancer
Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-N0192R

Arbutin (Standard)	Tyrosinase Endogenous Metabolite	Cancer
Arbutin (Standard) is the analytical standard of Arbutin. This product is intended for research and analytical applications. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-161846

Tyrosinase-IN-31	Tyrosinase	Neurological Disease
Tyrosinase-IN-31 (compound 2-06) is a central-targeting tyrosinase inhibitor (tyrosinase: monophenolase IC₅₀=70.44 μM, diphenolase IC₅₀=1.89 μM). Tyrosinase-IN-31 can inhibit the tyrosinase and melanogenesis. Tyrosinase-IN-31 can penetrate the BBB and enter the central nervous system (CNS). Tyrosinase-IN-31 shows neuroprotective effects and Parkinsonism behavior improving function .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

Cat. No.	Product Name	Target	Research Area

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1193

Sulfuretin	Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Anacardiaceae Toxicodendron vernicifluum (Stokes) F. A. Barkl.	NF-κB
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis . Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC₅₀ of 13.64 μM .

HY-N3200

Neorauflavane	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants	Tyrosinase
Neorauflavane is a potent tyrosinase inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-W015616

Benzylacetone 4-Penylbutan-2-one	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Thymelaeaceae Source classification Metabolic Disease Plants Aquilaria sinensis (Lour.) Spreng. Disease Research Fields	Tyrosinase
Benzylacetone is an aromatic compound from agarwood . Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity， with IC₅₀s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively . Benzylacetone has appetite-enhancing and locomotor-reducing effects .

HY-N0192

Arbutin 1 Publications Verification β-Arbutin	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Phenols Saxifragaceae Plants Endogenous metabolite Disease Research Fields Cancer	Tyrosinase Endogenous Metabolite
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i ^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-N2962

Broussonin C	Structural Classification Source classification Phenols Polyphenols Broussonetia × kazinoki Siebold Plants Moraceae	Tyrosinase
Broussonin C is a competitive inhibitor of Tyrosinase that can be isolated from Broussonetia kazinoki. Broussonin C inhibits *monophenolase* and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively .

HY-N0192R

Arbutin (Standard)	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Phenols Saxifragaceae Plants Endogenous metabolite	Tyrosinase Endogenous Metabolite
Arbutin (Standard) is the analytical standard of Arbutin. This product is intended for research and analytical applications. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

Cat. No.	Product Name	Chemical Structure

HY-N0192S

Arbutin-d4
Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

Arbutin-d4

Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

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Monophenolase

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products