2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Tyrosinase Sirtuin
  4. Decapeptide-12

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

For research use only. We do not sell to patients.

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Decapeptide-12 Chemical Structure

Decapeptide-12 Chemical Structure

CAS No. : 137665-91-9

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Decapeptide-12 Related Antibodies

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Description

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

IC50 & Target

IC50: 40 µM (Tyrosinase)[1], Kd: 61.1 μM (Tyrosinase)[2].
In Vitro

Decapeptide-12 (P4, 0.01-10 mΜ) dose-dependently inhibits mushroom tyrosinase with an IC50 value of 40 μM, and inhibits human tyrosinase by 25-35% at 100 μM[1].
Decapeptide-12 (100 μM, 7 days) leads to 43% reduction in melanin content in melanocytes with no effect on cell proliferation[1].
Decapeptide-12 (peptide P4, 0-400 μM) inhibits the monophenolase reaction with an IC50 value of 123 μM[2].
Decapeptide-12 interact with tyrosinase with a Kd value of 61.1 μM[2].
Decapeptide-12 (100 μM, 72 h) increases transcription of SIRT1, SIRT3, SIRT6, and SIRT7 with reduced cytotoxicity in human neonatal keratinocyte progenitors[3].
Decapeptide-12 (0-1 mM, 72 h) reduces Phytohemagglutinin (PHA)-stimulated PBMC cells proliferation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Decapeptide-12 Related Antibodies

Cell Proliferation Assay[3]

Cell Line: Phytohemagglutinin (PHA)-stimulated PBMC cells
Concentration: 0, 0.025, 0.05, 0.1, 0.3, 1 mM
Incubation Time: 72 h
Result: Reduced cell proliferation by 28% at 0.05 mM and 54% at 0.1 mM.

RT-PCR[3]

Cell Line: Human neonatal keratinocyte progenitors
Concentration: 3, 10, 30, 50, 100, 300, 500, 1000 μM
Incubation Time: 72 h
Result: Increased transcription of SIRT1 by 141% relative to untreated cells, increased SIRT3, SIRT6 and SIRT7 by 121%, 147% and 95%, respectively.
Molecular Weight

1395.52

Formula

KS3WY3
CAS No.
Sequence Shortening

YRSRKYSSWY
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Decapeptide-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decapeptide-12137665-91-9Decapeptide12Decapeptide 12TyrosinaseSirtuinMelanocytesmelaninmelanogenesismushroom tyrosinasemonophenolaseoligopeptideanti-senescenceanti-aginganti-inflammationInhibitorinhibitorinhibit

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