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OICR-8268-acrylic acid-amino-PEG9-amine

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169391
    OICR-8268-acrylic acid-amino-PEG9-amine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    OICR-8268-acrylic acid-amino-PEG9-amine is an E3 ligase ligand-linker conjugate. OICR-8268-acrylic acid-amino-PEG9-amine can be used to synthesize OICR41114 (HY-169389) .
    OICR-8268-acrylic acid-amino-PEG9-amine
  • HY-169389
    OICR41114

    		PROTACs WDR5 Cancer
    OICR41114 (PROTAC 4) is a WDR5-targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC50 and Dmax values of 40 nM and 49%, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner . OICR41114 is composed of target protein ligand (red part) Dimethyl-F-OICR-9429-COOH (HY-141799), E3 ligase ligand (blue part) OICR-8268-acrylic acid (HY-169390) and PROTAC linker (black part) Amino-PEG9-amine (HY-140210). The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid-amino-PEG9-amine (HY-169391).
    OICR41114

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