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PHD3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIF/HIF Prolyl-Hydroxylase (7) Histone Demethylase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

8

Inhibitors & Agonists

1

Peptides

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

AKB-6899	HIF/HIF Prolyl-Hydroxylase	Cancer
AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects .

TP0463518	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a K_i value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC₅₀s of 18 and 63 nM as well as monkey PHD2 with an IC₅₀ value of 22 nM .

JNJ-42041935	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase *PHD; inhibits PHD1, PHD2, and PHD3* with pK_i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively.

GSK360A	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
GSK360A is a potent and orally active *HIF-PHD* inhibitor with IC₅₀ values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) .

Molidustat 5+ Cited Publications BAY 85-3934	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC₅₀ values of 480 nM, 280 nM, and 450 nM for *PHD1, PHD2, and PHD3*, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia .

JHDM-IN-1	Histone Demethylase	Cancer
JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC₅₀s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively .

*HIF-PHD-IN-2*	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-PHD-IN-2 (compound 25) is a potent *PHD* inhibitor with IC₅₀s of <100 nM for PHD1, PHD2 and PHD3, respectively .

Molidustat sodium	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Molidustat sodium is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC₅₀ values of 480 nM, 280 nM, and 450 nM for *PHD1, PHD2, and PHD3*, respectively. Molidustat sodium can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat sodium can be utilized in the research of renal anemia .

Cat. No.	Product Name	Target	Research Area

*PhD3*	Peptides	Infection
PhD3 is an antimicrobial peptide derived from monkey white blood cells. PhD3 has activity against bacteria and fungus Candida albicans .

Cat. No.	Compare	Product Name	Application	Reactivity

	PHD3 Antibody (YA1612) PHD3; HIFPH3; HIFP4H3	WB, IHC-P, IP	Human, Mouse, Rat
	PHD3 Antibody (YA1612) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1612), targeting PHD3, with a predicted molecular weight of 27 kDa (observed band size: 27 kDa). PHD3 Antibody (YA1612) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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