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Pathways Recommended: PROTAC
Results for "

PROTAC PARP1 degrader-3

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168722
    PROTAC PARP1 degrader-3

    		PARP Cancer
    PROTAC PARP1 degrader-3 (Compound C6) is a degrader for PARP1 with a DC50 of 58.14 nM. PROTAC PARP1 degrader-3 exhibits cytotoxicity in cancer cell SW-620 and LOVO with IC50 of 1.63 μM and 2.84 μM. PROTAC PARP1 degrader-3 exhibits a synergistic effect with SN-38 (HY-13704) in BRCA-mutated colon cancer cell with a combination index (CI) of 0.487. (Blue: Ligand for E3 ligase Cereblon (HY-23095); Pink: Ligand for target protein (HY-10619); Black: Linker (HY-16872))
    PROTAC PARP1 degrader-3
  • HY-168723
    Piperidine-C-Pip-C2-Pip-C2-OH

    		PROTAC Linkers Cancer
    Piperidine-C-Pip-C2-Pip-C2-OH is a PROTAC Linker that can be used to synthesize the PROTAC PARP1 degrader-3 (HY-168722) for tumor research .
    Piperidine-C-Pip-C2-Pip-C2-OH

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