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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

SARS-CoV papain-like protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (16) Virus Protease (2) Bacterial (1) Deubiquitinase (1) Fluorescent Dye (1) HIF/HIF Prolyl-Hydroxylase (1)
By Research Areas:	Cancer (1) Infection (16) Inflammation/Immunology (1)

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Targets Recommended: SARS-CoV Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) Polo-like Kinase (PLK) NOD-like Receptor (NLR) Toll-like Receptor (TLR) Ser/Thr Protease ClpP KLF ANGPTL PERK ULK METTL3 MASTL Enteropeptidase ADAMTS IGF-1R LOX-1 Nuclear Hormone Receptor 4A/NR4A FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150784

XR8-89	SARS-CoV	Infection
XR8-89 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research .

HY-N1910

4'-O-Methylbavachalcone 1 Publications Verification	SARS-CoV	Infection
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-168584

SARS-CoV-2-IN-102	SARS-CoV	Infection
SARS-CoV-2-IN-102 (example 58) is a SARS-CoV papain-like protease (PLpro) inhibitor with an IC₅₀ <100 nM .

HY-161729

PLpro-IN-3	SARS-CoV	Infection
PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC₅₀ of 1.0μM. PLpro-IN-3 exhibits antiviral activity against *SARS-CoV-2* with a EC₅₀ of 4.3 μM .

HY-150783

SARS-CoV-2-IN-24	SARS-CoV	Infection
SARS-CoV-2-IN-24 (compound 7) is a potent papain-like protease (PL ^pro) inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .

HY-P2296

Abz-FRLKGGAPIKGV-EDDNP TFA	Fluorescent Dye	Others
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .

HY-150786

PLP_Snyder530	SARS-CoV	Infection
PLP_Snyder530 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research .

HY-150789

SARS-CoV-2-IN-23	SARS-CoV	Infection
SARS-CoV-2-IN-23 (compound GRL-0617) is a *SARS-COV-2* papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

HY-157439

SARS-CoV-2-IN-72	SARS-CoV	Infection
SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the *SARS-COV-2 papain-like* protease domain that can trigger the degradation of NSP3 .

HY-161365

PLpro-IN-2	SARS-CoV	Infection
PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC₅₀ of 0.25 μM .

HY-17542

PLpro inhibitor 5+ Cited Publications	SARS-CoV	Infection
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC₅₀ of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC₅₀ of 5.0 µM and an EC₅₀ of 21.0 µM .

HY-117043

GRL0617 Maximum Cited Publications 10 Publications Verification	Deubiquitinase SARS-CoV	Infection
GRL0617 is a selective and competitive noncovalent inhibitor of *severe acute respiratory syndrome (SARS-CoV) papain-like* protease (PLpro), with an IC₅₀** of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC₅₀ of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .

HY-159655

PLpro-IN-6	SARS-CoV	Infection Inflammation/Immunology
PLpro-IN-6 (compound 6) is a papain-like protease (PLpro) inhibitor, with an IC₅₀ of 0.019 μM for SARS CoV2 PLpro enzyme .

HY-169092

PF-07957472	SARS-CoV Virus Protease	Infection
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC₅₀ = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .

HY-157403

Jun12682	SARS-CoV	Infection
Jun12682 is an inhibitor of SARS-CoV-2 papain-like protease. Jun12682 inhibits PL ^pro with a K_i value of 37.7 nM. Jun12682 has EC₅₀ value of 1.1 μM in the FlipGFP PL ^pro assay. Jun12682 has orally activity .

HY-W088075

Acriflavine hydrochloride 5+ Cited Publications Acriflavinium chloride hydrochloride	HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV	Infection Cancer
Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye that can be used to label nucleic acid . Acriflavine hydrochloride is an antiseptic. Acriflavine hydrochloride is a potent HIF-1 inhibitor, with antitumor activity. Acriflavine hydrochloride has antimicrobial and antiviral activities . Acriflavine hydrochloride is a potent papain-like protease (PL ^pro) inhibitor, which inhibits SARS-CoV-2

HY-162484

GZNL-P36	SARS-CoV Virus Protease	Infection
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PL ^pro), with an IC₅₀ of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC₅₀ range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration C_max of 549 ng/mL, a half-life T_1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse .

Cat. No.	Product Name	Target	Research Area

HY-P2296

Abz-FRLKGGAPIKGV-EDDNP TFA	Fluorescent Dye	Others
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .

4'-O-Methylbavachalcone 1 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	SARS-CoV
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

Species:	Virus (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P74581

	SARS-CoV Plpro/papain-like protease Protein (His) SARS-CoV (strain WH20) Plpro / papain-like protease	Virus	E. coli
	SARS CoV ORF1ab polyprotein (PP1ab) is a 7073 residues long polyprotein which further produces 5 non-structural proteins (NSPs) after processing through virally encoded proteases (NSP12-NSP16).All these 5 proteins are mainly involved in viral replication, assembly, and immune response modulation.SARS-CoV Plpro/papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV Plpro/papain-like protease protein, expressed by E.coli , with C-His labeled tag.

HY-P70122

	SARS-CoV-2 PLpro Protein 1 Publications Verification rReplicase polyprotein 1ab/2019-nCoV papain-like protease; papain-like protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PLpro Protein is the recombinant Virus-derived SARS-CoV-2 PLpro protein, expressed by E. coli , with tag free. The total length of SARS-CoV-2 PLpro Protein is 315 a.a., with molecular weight of ~34.0 kDa.

HY-P76021

	SARS-CoV-2 Plpro/Papain-like protease Protein (His) SARS-CoV-2 (2019-nCoV) Plpro/papain-like protease-His Protein	Virus	E. coli
	SARS-CoV-2 NSP3 (NSP3) is one of non-structure protein that binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and contributes in polyprotein processing. NSP3 has also an important role in innate immune response antagonism and is responsible for release of NSP1, NSP2, and NSP3 from the N-terminal region of pp1a and pp1ab. SARS-CoV-2 Plpro/Papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV-2 Plpro/Papain-like protease protein, expressed by E. coli , with N-His labeled tag.

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SARS-CoV papain-like protease

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