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SJ 46421

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168634
    SJ46421

    		PROTACs Epigenetic Reader Domain Cancer
    SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2 PROTAC protein degrader. SJ46421 is able to promote a substantially tight ternary complex with KLHDC2 with an IC50 of 7.8 nM. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536)) .
    SJ46421
  • HY-168635
    SJ46420

    		PROTACs Epigenetic Reader Domain Cancer
    SJ46420, a SJ46421 (HY-168634) pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-159973)) .
    SJ46420

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