2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. SJ46420

SJ46420, a SJ46421 (HY-168634) pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-159973)).

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SJ46420 Chemical Structure

SJ46420 Chemical Structure

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SJ46420 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

SJ46420, a SJ46421 (HY-168634) pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-159973))[1].

IC50 & Target[1]

VHL

 

BRD3

 

Molecular Weight

851.44

Formula

C43H43ClN8O5S2
SMILES

O=C(OC)CNC(CC1=CSC(C2=CC=C3C=CC=C(OCCN4CCN(C(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)CC4)C3=C2)=N1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJ46420 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ46420SJ 46420SJ-46420PROTACsEpigenetic Reader DomainPROTAC BRD3 degraderInhibitorinhibitorinhibit

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HY-168635
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