1. PROTAC Epigenetics
  2. PROTACs Epigenetic Reader Domain
  3. SJ46421

SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2 PROTAC protein degrader. SJ46421 is able to promote a substantially tight ternary complex with KLHDC2 with an IC50 of 7.8 nM. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536)).

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SJ46421 Chemical Structure

SJ46421 Chemical Structure

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Description

SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2 PROTAC protein degrader. SJ46421 is able to promote a substantially tight ternary complex with KLHDC2 with an IC50 of 7.8 nM. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536))[1].

IC50 & Target[1]

VHL

 

BRD3 BD2

987 nM (Kd)

BRD4 BD2

1020 nM (Kd)

BRD2 BD2

2090 nM (Kd)

Molecular Weight

837.41

Formula

C42H41ClN8O5S2

SMILES

O=C(O)CNC(CC1=CSC(C2=CC=C3C=CC=C(OCCN4CCN(C(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)CC4)C3=C2)=N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SJ46421 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SJ46421
Cat. No.:
HY-168634
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