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TFEB

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By Targets:	Amyloid-β (2) Autophagy (5) Biochemical Assay Reagents (1) CDK (1) COX (2) Dopamine Transporter (1) Parasite (1) Small Interfering RNA (siRNA) (1) TNF Receptor (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Decoy ODNs (1) Pre-designed siRNA Sets (1) siRNAs (1)

12

Inhibitors & Agonists

3

Natural
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1

Recombinant Proteins

1

Antibodies

2

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TFEB activator 1 4 Publications Verification	Autophagy	Neurological Disease
TFEB activator 1 is an orally effective, mTOR-independent activator of *TFEB. TFEB* activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC₅₀ of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment .

20-Deoxyingenol 3 Publications Verification	Autophagy	Inflammation/Immunology
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

THZ-P1-2 2 Publications Verification	Autophagy	Cancer
THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC₅₀ of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines .

Subtilisin, bacillus licheniformis Bacillopeptidaseb	Biochemical Assay Reagents	Others
Subtilisin (Compound proteinase) (EC 3.4.21.62) is a proteolytic enzyme, isolated from Bacillus licheniformis. Subtilisin (Compound proteinase) has catalytic activity in anhydrous dimethyl formamide. Subtilisin (Compound proteinase) can be used as a catalyst for easy coupling between sugars and amino acids .

TFEB activator 2	Amyloid-β	Neurological Disease
TFEB activator 2 (compound 37) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 2 has effect on TFEB nuclear translocation with 72% (10μM 3h) and 94 % (30 μM 3h). TFEB activator 2 plays an important role in Alzheimer’s disease (AD). TFEB activator 2 can pass blood brain barrier .

TFEB activator 3	Amyloid-β	Neurological Disease
TFEB activator 3 (compound 45) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 3 has effect on TFEB nuclear translocation with 44% (10μM 3h) and 97 % (30 μM 3h). TFEB activator 3 plays an important role in Alzheimer’s disease (AD). TFEB activator 3 can pass blodd brain barrier .

TFEB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TFEB Human Pre-designed siRNA Set A contains three designed siRNAs for TFEB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFEB Human Pre-designed siRNA Set A TFEB Human Pre-designed siRNA Set A

MC2646	Autophagy Parasite	Infection
MC2646 is a potent anti-parasite agent. MC2646 induces autophagic. MC2646 activates the AMPK/TFEB pathway .

CXM102	Autophagy	Metabolic Disease
CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .

LH2-051	Dopamine Transporter CDK	Neurological Disease
LH2-051 is a lysosome-enhancing lead compound, which promotes the lysosome biogenesis and the Aβ aggregate clearance through dopamine transporter-cyclin-dependent kinase 9-transcription factor EB (DAT-CDK9-TFEB) pathway. LH2-051 exhibits good pharmacokinetic characteristics in mouse models. LH2-051 is potential for ameliorating Aleheimer’s Disease .

Aurantio-obtusin 1 Publications Verification	TNF Receptor COX	Cardiovascular Disease Inflammation/Immunology
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation .

Aurantio-obtusin (Standard)	TNF Receptor COX	Cardiovascular Disease Inflammation/Immunology
Aurantio-obtusin (Standard) is the analytical standard of Aurantio-obtusin. This product is intended for research and analytical applications. Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy-and AMPK/TFEB mediated inhibition of lipid accumulation .

Cat. No.	Compare	Product Name	Species	Source

	TFEB protein, Human (N-His) ALPHATFEB; BHLHE35; TCFEB	Human	E. coli
	TFEB Protein, a transcription factor, masterfully regulates lysosomal functions, autophagy, lipid catabolism, energy metabolism, and immune responses. Recognizing E-box and CLEAR-box sequences, it controls gene expression in response to nutrient availability. MTOR phosphorylation inhibits TFEB, retaining it cytosolic, while starvation induces dephosphorylation, leading to nuclear localization and gene activation. TFEB promotes autophagy and plays a role in immune responses, including antibacterial defense. The drug eltrombopag inhibits TFEB by binding to its bHLH domain, disrupting DNA-binding. TFEB protein, Human (N-His) is the recombinant human-derived TFEB protein, expressed by E. coli , with N-His labeled tag. The total length of TFEB protein, Human (N-His) is 476 a.a., with molecular weight of ~57.0 kDa.

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	Transcription Factor EB Antibody (YA3266) TFEB; BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Transcription Factor EB Antibody (YA3266) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3266), targeting Transcription Factor EB, with a predicted molecular weight of 53 kDa (observed band size: 65-70 kDa). Transcription Factor EB Antibody (YA3266) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

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Cat. No.	Product Name		Classification

TFEB Decoy ODN sodium		Decoy ODNs
TFEB Decoy ODN sodium is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB). TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects.

TFEB Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TFEB Human Pre-designed siRNA Set A contains three designed siRNAs for TFEB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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