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Isoforms Recommended: TRPC
Results for "

TRPC7

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111925
    BI-749327
    10+ Cited Publications

    		 TRP Channel Cardiovascular Disease
    BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7 .
    BI-749327
  • HY-RS15110
    TRPC7 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TRPC7 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TRPC7 Human Pre-designed siRNA Set A
    TRPC7 Human Pre-designed siRNA Set A
  • HY-111527
    PPZ2

    		Others Neurological Disease
    PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .
    PPZ2
  • HY-162090
    TRPC antagonist 1

    		TRP Channel Cancer
    TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines .
    TRPC antagonist 1

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