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Thalidomide-NH-C2-2-azaspiro[3.3]heptane

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153368
    Zomiradomide

    KT-413

    		 IRAK PROTACs Cancer
    KT-413 (example I-3) is an orally active PROTAC-class IRAK degrader . KT-413 consists of a target protein ligand (red part) PROTAC IRAK4 ligand-5 (HY-168311), an E3 ubiquitin ligase ligand (blue part) Thalidomide-4-Br (HY-W039116), and a PROTAC linker (black part) 2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine (HY-168313). E3 ubiquitin ligase and linker can form Thalidomide-NH-C2-2-azaspiro[3.3]heptane (HY-168312). The active control for the target protein ligand is RSL3-4-Me (HY-169375).
    Zomiradomide
  • HY-168312
    Thalidomide-NH-C2-2-azaspiro[3.3]heptane

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-NH-C2-2-azaspiro[3.3]heptane is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of KT-413 (HY-153368) .
    Thalidomide-NH-C2-2-azaspiro[3.3]heptane

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