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Results for "

Tiam1

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Peptides

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115376
    Z62954982

    ZINC08010136

    		 Ras Inflammation/Immunology
    Z62954982 (ZINC08010136) is a potent, selective and?cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 μM). Z62954982?disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA) [1] .
    Z62954982
  • HY-16659
    EHT 1864
    10+ Cited Publications

    		 Ras Neurological Disease Cancer
    EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG [1] .
    EHT 1864
  • HY-P1382A
    Rac1 Inhibitor W56 TFA

    		Ras Cancer
    Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam .
    Rac1 Inhibitor W56 TFA
  • HY-104064
    1A-116
    5 Publications Verification

    		 Ras Apoptosis Cancer
    1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo [1] .
    1A-116
  • HY-RS14515
    TIAM1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TIAM1 Human Pre-designed siRNA Set A contains three designed siRNAs for TIAM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TIAM1 Human Pre-designed siRNA Set A
    TIAM1 Human Pre-designed siRNA Set A
  • HY-P1382
    Rac1 Inhibitor W56

    		Ras Cancer
    Rac1 Inhibitor W56 is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam .
    Rac1 Inhibitor W56

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