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Results for "

USP1-IN-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145471
    KSQ-4279
    1 Publications Verification

    USP1-IN-1

    		 Deubiquitinase Apoptosis Cancer
    KSQ-4279 (USP1-IN-1) is a potent, first-in-class, and highly selective USP1 inhibitor. KSQ-4279 shows anticancer effects .
    KSQ-4279
  • HY-15757
    SJB2-043
    3 Publications Verification

    		 Deubiquitinase Cancer
    SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM.
    SJB2-043
  • HY-12988
    C527
    1 Publications Verification

    		 Deubiquitinase Cancer
    C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
    C527
  • HY-17543
    ML-323
    Maximum Cited Publications
    12 Publications Verification

    		 Deubiquitinase Cancer
    ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.
    ML-323
  • HY-153365
    I-138

    		Deubiquitinase Cancer
    I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells .
    I-138
  • HY-162633
    USP1-IN-9

    		Deubiquitinase Cancer
    USP1-IN-9 (Compound 1m) is reversible and noncompetitive ubiquitin-specific proteases (USP1) inhibitors with an IC50 of 8.8 nM, which is designed and synthesized to pyrido[2,3-d]pyrimidin-7(8H)-one derivative based on the disclosed structure of ML323(HY-17543) and KSQ-4279(HY-145471). USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib(HY-10162) in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer .
    USP1-IN-9

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